Transcription Factor
| Accessions: | Barhl1_DBD (HumanTF 1.0), UP00166A (UniPROBE 20160601) |
| Names: | Bar-class homeodomain protein MBH2, BarH-like 1 homeobox protein, BarH-related homeobox protein 1, BARH1_MOUSE, Barhl1, BarH-like 1 (Drosophila), Bhx1, Dres115 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P63157 |
| Description: | BarH-like 1 (Drosophila) |
| Notes: | Ensembl ID: ENSMUSG00000026805; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 EISSSRGSPPVRLKKPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQV 60 61 KTWYQNRRTKWKRQTAVGLELLAEAGNYSALQR |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 5zfz_A, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 6m3d_C, 2ld5_A, 7q3o_C, 6es3_K, 1b72_A, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 1e3o_C, 1au7_A, 7xrc_C, 2xsd_C, 1le8_A, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 1puf_B, 1k61_B |
| Binding Motifs: | UP00166A_1 aamAAcCAATTArkwc Barhl1_DBD_1 vyTAAayGgy Barhl1_DBD_2 syTAAwtGsy Barhl1_DBD_3 TAAwyGsysyTAAwyG |
| Binding Sites: | AACAATTA ACCAATTA ACCGTTTA ACTAATTG AGCAATTA ATAAACGG ATAATTGG ATCAATTA CAATTAAC CAATTAGC CAATTAGG CCAATTAA CCAATTAG CCGTTTAA CCGTTTAG CGTTTAGC CTAATTGC GACAATTA GCAATTAA GGCAATTA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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