Transcription Factor
| Accessions: | UP00584C (UniPROBE 20160601) |
| Names: | Aristaless-related homeobox, ARX_P353L, CT121, EIEE1, homeobox protein ARX, ISSX, MRX29, MRX32, MRX33, MRX36, MRX38, MRX43, MRX54, MRX76, MRX87, MRXS1, PRTS |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein ARX: Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate. |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 AGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYLDVFTREELAMRLDLTEARVQV 60 61 WFQNRRAKWRKREKAGAQTHPPGLPF |
| Interface Residues: | 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 70, 71 |
| 3D-footprint Homologues: | 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1nk2_P, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 3lnq_A, 2lkx_A, 1jgg_B, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 7psx_B, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 1b72_A, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 1k61_B, 1o4x_A, 8g87_X |
| Binding Motifs: | UP00584C_1 aakwkcgCTAATTAGybsrygy UP00584C_2 kavwsrsCyAATTrGyysmrka |
| Binding Sites: | AATTAATT ACCAATTA ACTAATTA ACTAATTG ATAATTAG ATAATTGG ATCAATTA ATTAATTA CCAATTAA CCAATTAG CCCAATTA CCTAATTA CTAATTAA CTAATTAC CTAATTAG CTAATTGA CTTAATTA GCCAATTA GCTAATTA GTTAATTA TAATTAGA TAATTGGA TTAATTAA CCAATTAC CTCAATTA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.