Transcription Factor
| Accessions: | UP00387A (UniPROBE 20160601) |
| Names: | HLH-1, MyoD1 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P22980 |
| Description: | Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals |
| Length: | 319 |
| Pfam Domains: | 151-202 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 NTETSTQSAPSDTYDTSIYYNSSPRVTANDITTLTSFAAPAPQVLDYANTQYDIYRNQPA 60 61 YYLPSYAPTAPTTFYSDFANFNVTRSQDFASVPAVANSSDVKPIIIKQEKSTPNATELII 120 121 QSRVDSQHEDTTTSTAGGAGVGGPRRTKLDRRKAATMRERRRLRKVNEAFEVVKQRTCPN 180 181 PNQRLPKVEILRSAIDYINNLERMLQQAGKMTKIMEQNQHLQMTQQINGAPPHDYVTSSH 240 241 FASSSYNPENMFDDDDLTDSDDDRDHHKLGNAVDLRRRNSLDRLSRIVASIPNEEAMTDE 300 301 QLLQPANDVIDGEKKLEML |
| Interface Residues: | 152, 155, 156, 158, 159, 160, 162, 163, 179, 180, 183, 184, 187 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 6od3_F, 2ql2_D, 2ypa_B, 2ql2_A, 8i54_A |
| Binding Motifs: | UP00387A_1 ksrACAGCTGTyrwrr |
| Binding Sites: | ATTATAAT TCAGCTGA AACAGCTG AACATATG AATCAGCT ACAGCTGA ACAGCTGG ACAGCTGT ACATATGA ACCAGCTG ATCAGCTG ATCAGGTG ATCATATG CACAGCTG CAGCTGAC CAGCTGAG CAGCTGTA CAGCTGTC CCAGCTGA TCATATGA |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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