Transcription Factor
| Accessions: | UP00364A (UniPROBE 20160601) |
| Names: | HLH-27 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q18056 |
| Description: | Helix Loop Helix Protein 27: hlh-27 encodes a REF-1-like protein with two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is trans |
| Length: | 267 |
| Pfam Domains: | 92-147 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 PKVIPSSMSDYRSVPYNQTPKSGSERKRRNITNELINECKTIVQKSEEEHISQEVVLFRI 60 61 VKLVTGVNLESNFSSNDLSESTRRKFDTESERRKVKTEREKIRRKKQDDCYAELKFFILN 120 121 KQMGSYEQRLKLERITILEIIIDYIKHNSDLLYPETIPQILPLLAGKSTATCENKENEKP 180 181 KTRMEVKDLFPRLTFQEVQESPTSTSPLLTFPCIPMIPTTQFNVLSNYNTVPSIFSAPLR 240 241 FILPSLQILTPETSDEEENEETVDISN |
| Interface Residues: | 93, 97, 99, 100, 103, 104 |
| 3D-footprint Homologues: | 2ypa_A |
| Binding Motifs: | UP00364A_1 rkrCgCGTGTCCcwd |
| Binding Sites: | ACACGCGC ACACGCGT ACACGTGT ACATGCGT ACGCATGG ACGCGTGG AGGACACG CACGCGTA CACGCGTG CACGTGTC CATGCGTA CCACGCGC CGCATGGC CGCATGTC CGCGTGGC CGCGTGTC CGTGTCCC CGTGTGTC GCATGTCC GCGTGTCC |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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