Transcription Factor
| Accessions: | UP00148A (UniPROBE 20160601) |
| Names: | Hdx, Highly divergent homeobox, Not Available |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q14B70 |
| Description: | Highly divergent homeobox |
| Length: | 518 |
| Pfam Domains: | 440-497 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MNLRSVFTVEQQRILQRYYENGMTNQSKNCFQLILQCAQETKLDFSVVRTWVGNKRRKMS 60 61 SKSCESGAAGTVSGTSLAAPDITVRNVVNIARPSSQQSSWTSANNDVIVTGIYSPVSSSS 120 121 KQGTTKHTNTQITEAHKIPIQKAANKNDTELQLHIPVQRQVAHCKNASVLLGEKTIILSR 180 181 QTSVLNAGNSVYNHTKKSYGSSPVQASEMTVPQKPSVCQRPCKIEPVGIQRSYKPEHAGL 240 241 ASHNLCGQKPTIRDPCCRTQNLEIREVFSLAVSDYPQRILGGNSTQKPASAEGTCLSIAM 300 301 ETGDAEDEYAREEELASMGAQITSYSRFYESGNSLRAENQSTNLPGPGRNLPNSQMVNIR 360 361 DLSDNVLYQTRDYHLTPRTSLHTASSTMYSNTNPSRSNFSPHFVSSNQLRLSQNQNNYQI 420 421 SGNLSVPWITGCSRKRALQDRTQFSDRDLATLKKYWDNGMTSLGSVCREKIEAVAIELNV 480 481 DCEIVRTWIGNRRRKYRLMGIEVPPPRGGPADFSEQPE |
| Interface Residues: | 4, 49, 50, 53, 54, 57, 58, 436, 441, 486, 487, 490, 491, 494, 495 |
| 3D-footprint Homologues: | 5hod_A, 1au7_A, 1k61_B, 8g87_X, 3d1n_M, 3a01_E, 2xsd_C, 7xrc_C, 1e3o_C, 1o4x_A, 2lkx_A, 3l1p_A |
| Binding Motifs: | UP00148A_1 wrkkmGAAATCAtcbha |
| Binding Sites: | AAAAATCA AAATCATG AACAATCA ACAATCAC ACAATCAG ACAATCAT ACGATCAT ACTATCAT AGAAATCA ATGATTGC ATGATTTC CACAATCA CGAAATCA GCAATCAC TAAGATCA TACAATCA TACGATCA TGAAATCA TGATATCA TGATTGCA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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