Transcription Factor
| Accessions: | Gbx1_DBD (HumanTF 1.0), UP00204A (UniPROBE 20160601) |
| Names: | Gastrulation and brain-specific homeobox protein 1, Gbx1, GBX1_MOUSE, Homeobox protein GBX-1, gastrulation brain homeobox 1 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P82976 |
| Description: | gastrulation brain homeobox 1 |
| Notes: | Ensembl ID: ENSMUSG00000067724; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 EGTPVATGVTTPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQV 60 61 KIWFQNRRAKWKRIKAGNVSSRSGEPVRNPKIV |
| Interface Residues: | 17, 18, 19, 20, 22, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 3cmy_A, 3d1n_M, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 1nk2_P, 1zq3_P, 6m3d_C, 4j19_B, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 1b72_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 4qtr_D, 1mnm_C, 1k61_B, 1o4x_A, 8g87_X, 1le8_B, 1du0_A |
| Binding Motifs: | UP00204A_1 wdsmaCYAATTRGtgbw Gbx1_DBD rcyAATTArs |
| Binding Sites: | GGTAATTA AATAATTA AATTAATT ACCAATTA ACTAATTA AGTAATTA ATAATTAG ATTAATTA CATAATTA CCAATTAG CCTAATTA GATAATTA GCAATTAA GCTAATTA GTAATTAA GTAATTAC GTTAATTA TAATTAGA TAATTGGA TTAATTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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