Transcription Factor
| Accessions: | UP00539A (UniPROBE 20160601) |
| Names: | AW546128, GLI-Kruppel family member GLI2, Gli2, Zinc finger protein GLI2 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | GLI-Kruppel family member GLI2 |
| Length: | 188 |
| Pfam Domains: | 18-41 Zinc finger, C2H2 type 18-41 C2H2-type zinc finger 49-76 Zinc finger, C2H2 type 69-94 Zinc-finger double domain 82-106 C2H2-type zinc finger 82-106 Zinc finger, C2H2 type 98-125 Zinc-finger double domain 112-137 C2H2-type zinc finger 112-137 Zinc finger, C2H2 type 131-155 Zinc-finger double domain 143-168 C2H2-type zinc finger 143-168 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 DRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQ 60 61 KPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCN 120 121 KAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRN 180 181 DVHVRAPL |
| Interface Residues: | 28, 29, 31, 32, 35, 64, 65, 66, 67, 68, 70, 71, 73, 74, 77, 94, 95, 96, 97, 98, 100, 101, 102, 124, 125, 126, 127, 128, 129, 130, 131, 132, 135, 155, 156, 157, 158, 159, 161, 162, 166, 176, 177, 178, 179, 182, 185 |
| 3D-footprint Homologues: | 5v3j_F, 1ubd_C, 6jnm_A, 3uk3_C, 8cuc_F, 7y3l_A, 7n5w_A, 6blw_A, 2gli_A, 1tf6_A, 6wmi_A, 5ei9_F, 7eyi_G, 8h9h_G, 2i13_A, 6e94_A, 6a57_A, 2jpa_A, 7w1m_H, 8ssu_A, 5kkq_D, 8ssq_A, 1tf3_A, 1mey_C, 5und_A, 1f2i_J, 5k5i_A, 2kmk_A, 6ml4_A, 8gn3_A, 1g2f_F, 6u9q_A, 5yel_A, 4x9j_A, 1llm_D, 7txc_E, 5kl3_A, 7ysf_A, 5yj3_D, 4m9v_C, 2lt7_A, 7y3m_I, 2drp_D, 2wbs_A |
| Binding Motifs: | UP00539A_1 / UP00539A_2 kyrshvrGACCACCCakrdygy UP00539A_3 rytmyyagCCyCCCACgtyrksk UP00539A_4 / UP00539A_5 ktmsdwrGACCACCCAgrwdgb UP00539A_6 wrykascgkGGGTGGCrrssray |
| Binding Sites: | ACCCCCCA CCCCCCAC GACCCCCC GCCACCCA GCCCACCC GGACCCCC ACCACCCA AGACCACC AGGCCACC AGGTGGTC CCACCCAC CCACCCAG CGACCACC CGGTGGTC GACCACCA GACCACCC GACCTCCC GGACCACC GGCCACCC GGGCCACC |
| Publications: | Peterson KA, Nishi Y, Ma W, Vedenko A, Shokri L, Zhang X, McFarlane M, Baizabal JM, Junker JP, van Oudenaarden A, Mikkelsen T, Bernstein BE, Bailey TL, Bulyk ML, Wong WH, McMahon AP. Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev 26:2802-16 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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