Transcription Factor
| Accessions: | UP00540A (UniPROBE 20160601) |
| Names: | add, AI854843, AU023367, Bph, brachyphalangy, GLI-Kruppel family member GLI3, Gli3, GLI3-190, GLI3FL, Pdn, Transcriptional activator GLI3, Xt, Zinc finger protein GLI3 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | GLI-Kruppel family member GLI3: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repres |
| Length: | 188 |
| Pfam Domains: | 18-41 Zinc finger, C2H2 type 18-41 C2H2-type zinc finger 49-76 Zinc finger, C2H2 type 69-94 Zinc-finger double domain 82-106 C2H2-type zinc finger 82-106 Zinc finger, C2H2 type 98-125 Zinc-finger double domain 112-137 Zinc finger, C2H2 type 112-137 C2H2-type zinc finger 131-155 Zinc-finger double domain 143-168 C2H2-type zinc finger 143-168 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 ADKDESKQEPEVIYETNCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQ 60 61 KPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCN 120 121 KAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRG 180 181 DMHPRPPP |
| Interface Residues: | 28, 29, 30, 31, 32, 35, 54, 64, 65, 66, 67, 68, 70, 71, 73, 74, 77, 94, 95, 96, 97, 98, 100, 101, 124, 125, 126, 127, 128, 129, 130, 131, 132, 135, 156, 157, 158, 159, 160, 161, 162, 163 |
| 3D-footprint Homologues: | 7w1m_H, 6wmi_A, 5v3j_F, 1ubd_C, 2kmk_A, 6jnm_A, 3uk3_C, 8cuc_F, 1tf3_A, 7y3l_A, 7n5w_A, 6blw_A, 1tf6_A, 5ei9_F, 5k5i_A, 6ml4_A, 2gli_A, 7eyi_G, 8h9h_G, 2i13_A, 6e94_A, 6a57_A, 2jpa_A, 5kkq_D, 8ssq_A, 8ssu_A, 6u9q_A, 5yel_A, 4x9j_A, 1llm_D, 7txc_E, 5kl3_A, 7ysf_A, 5yj3_D, 1mey_C, 5und_A, 1f2i_J, 1g2f_F, 2lt7_A, 7y3m_I, 2wbs_A, 2drp_D, 4m9v_C |
| Binding Motifs: | UP00540A_1 / UP00540A_2 sykksvrGACCACCCAcrwysmt UP00540A_3 kmTTvvCryGGwGGTCywrmyt UP00540A_4 / UP00540A_5 hasrgkgGACCACCCrgvdrgw UP00540A_6 rytcmhygCCaCmCacgckhgy |
| Binding Sites: | ACCCCCCA CCCCCCAC GACCCCCC GCCACCCA GCCCACCC ACCACCCA AGACCACC AGGTGGTC ATGGGTGG CCACCCAC CCACCCAG CCCACCCA CGACCACC CGGTGGTC GACCACAC GACCACCA GACCACCC GACCTCCC GGACCACC GGCCACCC |
| Publications: | Peterson KA, Nishi Y, Ma W, Vedenko A, Shokri L, Zhang X, McFarlane M, Baizabal JM, Junker JP, van Oudenaarden A, Mikkelsen T, Bernstein BE, Bailey TL, Bulyk ML, Wong WH, McMahon AP. Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev 26:2802-16 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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