Transcription Factor
| Accessions: | UP00592A (UniPROBE 20160601) |
| Names: | GFI1B_REF, Growth factor independent protein 1B, Potential regulator of CDKN1A translocated in CML, zinc finger protein Gfi-1b |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | zinc finger protein Gfi-1b: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 |
| Length: | 173 |
| Pfam Domains: | 6-29 Zinc finger, C2H2 type 6-29 C2H2-type zinc finger 21-46 Zinc-finger double domain 35-53 Zinc-finger of C2H2 type 35-57 C2H2-type zinc finger 35-57 Zinc finger, C2H2 type 35-54 C2H2-type zinc finger 49-74 Zinc-finger double domain 63-82 Zinc-finger of C2H2 type 63-85 C2H2-type zinc finger 63-85 Zinc finger, C2H2 type 63-81 C2H2-type zinc finger 78-101 Zinc-finger double domain 91-109 C2H2-type zinc finger 91-113 Zinc finger, C2H2 type 91-101 C2H2-type zinc finger 106-129 Zinc-finger double domain 118-141 C2H2-type zinc finger 119-141 C2H2-type zinc finger 119-141 Zinc finger, C2H2 type 133-156 Zinc-finger double domain 147-170 C2H2-type zinc finger 147-170 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 PGMDAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQE 60 61 RSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHK 120 121 CQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK |
| Interface Residues: | 17, 19, 20, 23, 43, 45, 46, 47, 48, 49, 52, 53, 56, 63, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 86, 101, 102, 103, 104, 105, 107, 108, 111, 129, 130, 131, 132, 133, 135, 136, 157, 158, 159, 160, 161, 162, 163, 164, 168 |
| 3D-footprint Homologues: | 8ssu_A, 6wmi_A, 5und_A, 5k5l_F, 8ssq_A, 1tf6_A, 5v3j_F, 7y3m_I, 8gh6_A, 5kkq_D, 6jnm_A, 5k5i_A, 7w1m_H, 4m9v_C, 6e94_A, 7ysf_A, 2i13_A, 5yel_A, 6a57_A, 1ubd_C, 2kmk_A, 7n5w_A, 5ei9_F, 8gn3_A, 2drp_D, 2gli_A, 6ml4_A, 8h9h_G, 7eyi_G, 2lt7_A, 2jpa_A, 1tf3_A, 2wbs_A, 6u9q_A, 1mey_C, 7txc_E, 5kl3_A, 1f2i_J, 1g2f_F, 4x9j_A, 6blw_A, 3uk3_C, 8cuc_F, 7y3l_A, 1llm_D, 5yj3_D |
| Binding Motifs: | UP00592A_1 ttwwtgkAAATCTGdwckgdstm UP00592A_2 kwwtrtcaAATCAswgmatawww |
| Binding Sites: | AGATTTAC GTAAATCA GTGATTGA AAAATCAC AAAATCAG AAAATCTG AAATCAAA AAATCACG AAATCACT AAATCAGA AAATCAGT AAATCTCT AAATCTGA AAATCTGG AAATCTGT AATCACAG AATCACGG AATCACTG AATCAGTG AATCTCAG AATCTGTG AGATTTAT CAAATCTG CAATCACG CAGATTTA CAGATTTC CTGATTTA GTGATTTA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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