Transcription Factor
| Accessions: | Hic1_DBD (HumanTF 1.0), UP00035A (UniPROBE 20160601) |
| Names: | Hic-1, Hic1, HIC1_MOUSE, Hypermethylated in cancer 1 protein, AA408311, hypermethylated in cancer 1 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q9R1Y5 |
| Description: | hypermethylated in cancer 1: Mus musculus hypermethylated in cancer 1 (Hic1) |
| Notes: | Ensembl ID: ENSMUSG00000043099; DNA-binding domain sequence; TF family: znfC2H2; Clone source: Hughes lab. |
| Length: | 207 |
| Pfam Domains: | 20-38 C2H2-type zinc finger 86-108 C2H2-type zinc finger 86-106 Zinc-finger of C2H2 type 86-109 C2H2-type zinc finger 86-108 Zinc finger, C2H2 type 101-125 Zinc-finger double domain 114-136 C2H2 type zinc-finger (2 copies) 114-136 C2H2-type zinc finger 114-137 C2H2-type zinc finger 114-136 Zinc finger, C2H2 type 116-136 Zinc-finger of C2H2 type 129-153 Zinc-finger double domain 142-164 Zinc finger, C2H2 type 142-164 C2H2-type zinc finger 142-162 C2H2-type zinc finger 157-180 Zinc-finger double domain 169-192 C2H2-type zinc finger 170-192 Zinc finger, C2H2 type 170-192 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 PHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAG 60 61 LGPPFGGGGDKVTGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICG 120 121 KKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFA 180 181 QQRNLISHMKMHAVGGAAGAAGALAGL |
| Interface Residues: | 2, 5, 27, 28, 29, 33, 41, 42, 45, 60, 64, 66, 67, 69, 70, 73, 75, 77, 78, 96, 97, 98, 99, 100, 102, 103, 105, 106, 109, 114, 124, 125, 126, 127, 128, 131, 132, 152, 153, 154, 155, 156, 157, 158, 159, 160, 162, 163, 164, 166, 167, 180, 181, 182, 183, 184, 186, 187, 191 |
| 3D-footprint Homologues: | 5v3j_F, 7w1m_H, 5yel_A, 8cuc_F, 7y3l_A, 1tf3_A, 2drp_D, 5k5i_A, 8ssq_A, 1tf6_A, 2gli_A, 8ssu_A, 6ml4_A, 6blw_A, 5kkq_D, 5ei9_F, 7eyi_G, 7ysf_A, 6wmi_A, 2lt7_A, 2i13_A, 6e94_A, 2jpa_A, 1ubd_C, 2kmk_A, 6jnm_A, 7n5w_A, 1g2f_F, 5und_A, 4x9j_A, 8gn3_A, 1mey_C, 6u9q_A, 7txc_E, 5kl3_A, 4m9v_C, 8h9h_G, 7y3m_I, 6a57_A, 3uk3_C, 5yj3_D, 1llm_D, 5k5l_F, 2wbs_A, 1f2i_J, 1yuj_A |
| Binding Motifs: | UP00035A_1 dykrTGCCAaCCtrcy Hic1_DBD_1 rTGCCAvCyyrTGCCAaC Hic1_DBD_2 rTGCCAaCc UP00035A_2 kggkrTGCCCawwmdv |
| Binding Sites: | AGGTGGCA AGTTGGCA ATGCCAAC ATGCCACC ATGCCAGC ATGCCCAC ATGCCCAT ATTGGCAC CGTTGGCA GATGCCCA GGGTGGCA GGTGCCCA GGTGGCAC GGTGGGCA GGTTGGCA GTGCCCAC TGCCCACA TGGGCACA TGTGCCAA GGTGCCAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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