DNA Binding Motif

						

			
Accessions: Hic1_DBD_2 (HumanTF 1.0), MA0739.1 (JASPAR 2024)

			
Names: Hic1
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomer; SELEX cycle: 4, HT-SELEX
Length: 9
Consensus: rTGCCAaCc
Weblogo: 
PSSM: P0      A      C      G      T
01   6337    719   4670    666      r
02     62    422     73  11007      T
03    950    588  11007    183      G
04     50  11007    121      0      C
05     88  11007     31     68      C
06   9008   1999      3    317      A
07   6140   1986   2267    614      a
08   1220  11007   1629   1488      C
09   1610   4822   1884   2692      c
Type: Heterodimer
Binding TFs: Hic1_DBD (Zinc finger, C2H2 type, C2H2 type zinc-finger (2 copies), Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
Q9R1Y5 (Zinc finger, C2H2 type, BTB/POZ domain, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
Q9R1Y5
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Pinte S., Stankovic-Valentin N., Deltour S., Rood B. R., Guerardel C., Leprince D. The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.. J. Biol. Chem. 279:38313-38324 (2004). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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