Transcription Factor
| Accessions: | EOMES_DBD (HumanTF 1.0), EOMES_TF2 (HumanTF2 1.0), EOMES (HT-SELEX2 May2017) |
| Names: | EOMES, EOMES_HUMAN, Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2, ENSG00000163508 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O95936 |
| Notes: | Ensembl ID: ENSG00000163508; DNA-binding domain sequence; TF family: T-box; Clone source: Gene synthesis, Ensembl ID: ENSG00000163508; Construct type: TF2(3xFLAG); TF family: Tbox; Clone source: Jolma et al. 2013, TF family: T_box experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: T_box experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 224 |
| Pfam Domains: | 20-208 T-box |
| Sequence: (in bold interface residues) | 1 GSCGGLGGLGVPSSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNP 60 61 TAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISF 120 121 GKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQF 180 181 IAVTAYQNTDITQLKIDHNPFAKGFRDNYDSSHQIVPGGRYGVQ |
| Interface Residues: | 45, 184, 185, 201, 204, 205 |
| 3D-footprint Homologues: | 4a04_B, 1h6f_B, 5flv_I, 1xbr_B, 6f59_B, 2x6v_A |
| Binding Motifs: | EOMES_DBD_1 aAGGTGTGAaawh EOMES_DBD_2 TmACACctwskragGTGTGA ALX4_EOMES skyGctAAytwwwktTvrCACmt E2F1_EOMES_1 vrGTGtGaAwgGCGCsywkCac E2F1_EOMES_2 rsGYGtsrwGGCGsywTgdCrbgg E2F3_EOMES argYGykAtGGCGCstTmrCrcyt ELK1_EOMES_1 rrGyGygrrrryrgkrtsrCrCCGGAAgy ELK1_EOMES_2 rcCGGAAGTrgGyGygA ELK1_EOMES_2_3 tmrCACCGGAAgy ERF_EOMES_1 rgGTGtgrvvdhrdwwtvdCACmGGAArb ERF_EOMES_2 waTmrCACMGGAwry ETV2_EOMES_1 agGYGtkamvtksmrttsrCrcMGGAwryg ETV2_EOMES_2 TcrCRCMGGAwry ETV2_EOMES_2_3 aCCGGAwryrmmwhyymACACctw ETV5_EOMES_1 rrGTGtkrdbskgrgkTsrCrsmGGAwgy ETV5_EOMES_2 ycrCrcCGGAwg GCM2_EOMES rTGCGGGhagGTGtga HOXA3_EOMES TAAyGagGTGtka HOXB13_EOMES_1 aggTGtswmATwAAa HOXB13_EOMES_2 cymrTwAawtmaCAccy HOXB2_EOMES_1 rgGYGyTAATkg HOXB2_EOMES_2 trAtkrgGTGyka HOXC10_EOMES TmaCACcTCrTaAa HOXD12_EOMES_1 agGyGyGAmrmwamatTmACACCTCrTaAa HOXD12_EOMES_2 tTwAYGAkswwCmTCGTwAA HOXD12_EOMES_2_3 TmrCACcTCrTwAA MEIS1_EOMES asgTGwkGaCAk MYBL1_EOMES_1 mcsyGacyAACsghmyycaCrCcy MYBL1_EOMES_2 rsGTGtshAACgg PITX1_EOMES_1 GGATTArcrgGTGtgr PITX1_EOMES_2 rgGTGTkAarkrGGATTA POU2F1_EOMES_1 wTATkCAgyGtka POU2F1_EOMES_2 rgTGtwrgaATATkcm POU2F1_EOMES_2_3 akGTGtwkGmATATkymyrCrswg POU2F1_EOMES_2_3_4 gawTATkCAGyGtkA POU2F1_EOMES_2_3_4_5 gmaTATKCrGyGykAwwtmrryttmrCrCb TEAD4_EOMES_1 ggyGybAMATwcytwtcrCrCy TEAD4_EOMES_2 rGaATGyGtkA- TEAD4_EOMES_2_3 wkGyGykAmATtcy TEAD4_EOMES_2_3_4 aggyGysACATTCCd TEAD4_EOMES_2_3_4_5 GGwATGyragGTGygr TEAD4_EOMES_2_3_4_5_6 rgGTGtkrssrkwGGwATGyg EOMES_2 rAGGTGTGAa EOMES_methyl_1 dAgGTGTgAw |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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