DNA Binding Motif

						

			
Accessions: POU2F1_EOMES_2_3_4_5 (HumanTF2 1.0)

			
Names: POU2F1_EOMES
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 30
Consensus: gmaTATKCrGyGykAwwtmrryttmrCrCb
Weblogo: 
PSSM: P0      A      C      G      T
01    692    416   1205    742      g
02   1155    905    465    530      m
03   1438    316    555    744      a
04    153    585    277   3055      T
05   3055      1      3     13      A
06     29     77    108   3055      T
07    177     10   3055   1235      K
08     74   3055    251    120      C
09   1495    265    899    395      r
10     95    471   2111    378      G
11    422   1278    108   1246      y
12    240     85   3055      5      G
13    442   1286    281   1769      y
14    707    968   3055   1850      k
15   3055    101    315    229      A
16   1216    444    562    832      w
17   1242    246    632    935      w
18    420    503    621   1512      t
19    889    939    723    504      m
20    835    706    847    666      r
21   1008    524    943    580      r
22    510    790    433   1321      y
23    716    743    650    945      t
24    462    555    183   1855      t
25    966   1185    738    166      m
26   1138    205    999    713      r
27     35   3055     49    175      C
28   1817     74   1238     79      r
29    316   3055    403    288      C
30    409    854    834    958      b
Type: Heterodimer
Binding TFs: EOMES_TF2 (T-box)
POU2F1_TF1 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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