Transcription Factor
| Accessions: | POU2F1_DBD (HumanTF 1.0), POU2F1_TF1 (HumanTF2 1.0) |
| Names: | NF-A1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, OTF-1, PO2F1_HUMAN, POU domain, class 2, transcription factor 1, POU2F1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P14859 |
| Notes: | Ensembl ID: ENSG00000143190; DNA-binding domain sequence; TF family: homeodomain+POU; Clone source: MGC, Ensembl ID: ENSG00000143190; Construct type: TF1(SBP); TF family: POU+Homeodomain; Clone source: Jolma et al. 2013 |
| Length: | 211 |
| Pfam Domains: | 24-97 Pou domain - N-terminal to homeobox domain 123-179 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MAPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLY 60 61 GNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLS 120 121 RRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRI 180 181 NPPSSGGTSSSPIKAIFPSPTSLVATTPSLV |
| Interface Residues: | 49, 64, 65, 66, 67, 68, 70, 71, 77, 81, 122, 123, 124, 125, 126, 127, 131, 164, 165, 167, 168, 171, 172, 175, 176, 179 |
| 3D-footprint Homologues: | 7u0g_M, 3d1n_M, 3l1p_A, 5t2o_A, 1e3o_C, 1au7_A, 7xrc_C, 2xsd_C, 8g87_X, 1o4x_A, 3a01_E, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 5zfz_A, 1ig7_A, 2lkx_A, 1zq3_P, 7q3o_C, 6es3_K, 1nk2_P, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 2hos_A, 1b72_A, 2d5v_B, 5hod_A, 5jlw_D, 2ld5_A, 1le8_A, 1jgg_B, 3lnq_A, 5flv_I, 4cyc_A, 7psx_B, 5zjt_E, 1du0_A, 4qtr_D |
| Binding Motifs: | POU2F1_DBD_1 awTATGcwAATt POU2F1_DBD_2 yaTrmATATkCAwa POU2F1_DLX2_1 tgAATATkcaTmCAcTAATTG POU2F1_DLX2_2 tGmATATkCahwmkTAATTr POU2F1_DLX2_2_3 wTwTGCRwAkyYAATtr POU2F1_ELK1_1 aCCGGAwATGCAw POU2F1_ELK1_2 mCCGsATATGCAm POU2F1_EOMES_1 wTATkCAgyGtka POU2F1_EOMES_2 rgTGtwrgaATATkcm POU2F1_EOMES_2_3 akGTGtwkGmATATkymyrCrswg POU2F1_EOMES_2_3_4 gawTATkCAGyGtkA POU2F1_EOMES_2_3_4_5 gmaTATKCrGyGykAwwtmrryttmrCrCb POU2F1_ETV1 aCCGGATATGCAw POU2F1_ETV4_1 / POU2F1_ETV4_2 ACCGgATATGCAd POU2F1_FOXO6_1 GmATATKCAwrwswysrammmawkrwmAACA POU2F1_FOXO6_2 GmATATkCawmwckkryskskdcrwmAACA POU2F1_FOXO6_2_3 gmATATkCAhrawwwhawrmmrtmAACA POU2F1_GSC2_1 / POU2F1_GSC2_2 mrgATTAwdyATkCawaww POU2F1_HOXB13 wrmATAwwCmAATAAA POU2F1_SOX15_1 wtGmATaACAAwr POU2F1_SOX15_2 wtGmATrACAAwr POU2F1_SOX15_2_3 ywtGmATAACAAwrra POU2F1_SOX2_1 aTTwrCATrACAAwrv POU2F1_SOX2_2 mATTWrCATmACAAWrg POU2F1_TBX21_1 hgTGydrgmATATkmthaCAcc POU2F1_TBX21_2 wTATkCAGyGywa |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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