DNA Binding Motif

						

			
Accessions: POU2F1_FOXO6_2 (HumanTF2 1.0)

			
Names: POU2F1_FOXO6
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 30
Consensus: GmATATkCawmwckkryskskdcrwmAACA
Weblogo: 
PSSM: P0      A      C      G      T
01    141     99    908    166      G
02    593    457     17    134      m
03   1050     44    120     46      A
04      0     29      0   1050      T
05   1050      0      2      2      A
06      4      2     35   1050      T
07     12      1    405    645      k
08     68   1050     16     20      C
09    650     83    248     69      a
10    322    199    234    294      w
11    516    285     49    200      m
12    309    159    194    388      w
13    163    529    101    255      c
14    183    251    270    346      k
15    160    199    291    399      k
16    347    146    364    193      r
17    189    328    224    308      y
18    180    306    367    197      s
19    199     67    357    427      k
20    192    392    274    192      s
21    200    130    376    343      k
22    372     59    323    295      d
23    146    497    234    173      c
24    603    132    446     14      r
25    390    141     52    660      w
26    480    570     14     49      m
27   1050    141      0     65      A
28   1050     37     87     36      A
29     54   1050     66    279      C
30   1050     24     11     69      A
Type: Heterodimer
Binding TFs: FOXO6_TF2 (Fork head domain)
POU2F1_TF1 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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