Transcription Factor
| Accessions: | FOXO6_DBD (HumanTF 1.0), FOXO6_TF2 (HumanTF2 1.0) |
| Names: | FOXO6, FOXO6_HUMAN, Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, HNF4A_HUMAN, Nuclear receptor subfamily 2 group A member 1, TCF-14, Transcription factor 14, Transcription factor HNF-4 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | A8MYZ6 |
| Notes: | Ensembl ID: ENSG00000204060; DNA-binding domain sequence; TF family: Forkhead; Clone source: Gene synthesis, Ensembl ID: ENSG00000204060; Construct type: TF2(3xFLAG); TF family: Forkhead; Clone source: Jolma et al. 2013 |
| Length: | 160 |
| Pfam Domains: | 39-121 Fork head domain |
| Sequence: (in bold interface residues) | 1 CGPERRATAPAMAPAPPLGAEVGPLRKAKSSRRNAWGNLSYADLITKAIESAPDKRLTLS 60 61 QIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGG 120 121 KTGKTPRRRAVSMDNGAKFLRIKGKASKKKQLQAPERSPD |
| Interface Residues: | 81, 84, 86, 87, 88, 90, 91, 92, 94, 95, 104, 109, 128 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 3qrf_G |
| Binding Motifs: | FOXO6_DBD_1 GTAAACATGTTTAC FOXO6_DBD_2 GTAAACA FOXO6_DBD_3 TTTCCCCACACGaC CUX1_FOXO6 rtmaaCaaahtrATCrATa E2F3_FOXO6_1 gaaTGACACGCGCCCmc E2F3_FOXO6_2 gaaTGACACcGCGCCCac ETV2_FOXO6 rCCGGAWGTTkwy POU2F1_FOXO6_1 GmATATKCAwrwswysrammmawkrwmAACA POU2F1_FOXO6_2 GmATATkCawmwckkryskskdcrwmAACA POU2F1_FOXO6_2_3 gmATATkCAhrawwwhawrmmrtmAACA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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