DNA Binding Motif

						

			
Accessions: POU2F1_ETV1 (HumanTF2 1.0), UN0579.1 (JASPAR 2024)

			
Names: POU2F1_ETV1, POU2F1::ETV1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 13
Consensus: aCCGGATATGCAw
Weblogo: 
PSSM: P0      A      C      G      T
01   1014    227    282    186      a
02    266   1709    277     58      C
03    149   1709     84      0      C
04     15      0   1709     15      G
05    190    144   1709     38      G
06   1709     46     25     94      A
07    349     12     10   1709      T
08   1709      4     25      1      A
09      0      0     59   1709      T
10     81      5   1709     77      G
11    128   1709     73    276      C
12   1709    107    495    148      A
13    533    250    262    663      w
Type: Heterodimer
Binding TFs: ETV1_TF2 (Ets-domain)
POU2F1_TF1 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
P50549 (Ets-domain, PEA3 subfamily ETS-domain transcription factor N terminal domain)
P50549
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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