DNA Binding Motif

						

			
Accessions: POU2F1_SOX2_1 (HumanTF2 1.0)

			
Names: POU2F1_SOX2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 16
Consensus: aTTwrCATrACAAwrv
Weblogo: 
PSSM: P0      A      C      G      T
01  17253   2167   1468   4889      a
02   1863    683    449  18642      T
03   2105   2838    440  17852      T
04  10171    732    391  16252      w
05   7627   1188  17147    417      r
06   3732  17560    295    746      C
07  18372    526    915    373      A
08     93     24     21  18885      T
09   8269   2722   5416   2502      r
10  18730    218    130   1360      A
11    605  17836   1345   2764      C
12  18854    237    114    249      A
13  18768    538    335    183      A
14   8073    980    506  16423      w
15   8445   2391   8412   2994      r
16   5045   4883   7114   1867      v
Type: Heterodimer
Binding TFs: POU2F1_TF1 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
SOX2_TF1 / SOX2_TF2 (HMG (high mobility group) box, Domain of unknown function (DUF1898), SOX transcription factor)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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