DNA Binding Motif

						

			
Accessions: POU2F1_SOX2_2 (HumanTF2 1.0), MA1962.1 (JASPAR 2024)

			
Names: POU2F1_SOX2, POU2F1::SOX2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 17
Consensus: mATTWrCATmACAAWrg
Weblogo: 
PSSM: P0      A      C      G      T
01   7886   4993   2541    825      m
02  15701    528    434   1325      A
03    553    216     22  16133      T
04   1136    552     53  16109      T
05   5710    471     65  14381      W
06   5841    812  10408     25      r
07   1656  15582     70    141      C
08  15595    113    501     35      A
09     32    154     49  16010      T
10   7899   5483   2557    306      m
11  16152    518    158    629      A
12    376  15839    683   2079      C
13  16231    175     89    372      A
14  16210    133     61    127      A
15   5996    340     87  13866      W
16   7139    636   7984   1558      r
17   2147   3768   8916   1414      g
Type: Heterodimer
Binding TFs: P48431 (HMG (high mobility group) box, Domain of unknown function (DUF1898), SOX transcription factor)
POU2F1_TF1 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
SOX2_TF1 / SOX2_TF2 (HMG (high mobility group) box, Domain of unknown function (DUF1898), SOX transcription factor)
P48431
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Malik V, Zimmer D, Jauch R. Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming. Cell Mol Life Sci 75:1587-1612 (2018). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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