DNA Binding Motif

						

			
Accessions: ETV2_EOMES_2 (HumanTF2 1.0), UN0511.1 (JASPAR 2024)

			
Names: ETV2_EOMES, ETV2::EOMES
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 13
Consensus: TcrCRCMGGAwry
Weblogo: 
PSSM: P0      A      C      G      T
01    414    583    243   3174      T
02   1506   3174   1448    610      c
03   3174    379   1711    524      r
04    102   3174     24     66      C
05   3174     63   1112     40      R
06    421   3174    429     74      C
07   1169   3174     83      2      M
08     40      1   3174      3      G
09      0      0   3174      6      G
10   3174      3     14     47      A
11   1714    156     78   1460      w
12   1114    392   2060    130      r
13    300   1554    495   1620      y
Type: Heterodimer
Binding TFs: EOMES_TF2 (T-box)
ETV2_TF1 (Ets-domain)
Q3KNT2 (Ets-domain)
Q3KNT2
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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