footprintDB - a database of transcription factors with annotated cis elements (DNA motifs and sites) and binding interfaces

Database 'UniPROBE 20160601' (Transcription Factors 351-400)

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Accessions	Names	Organisms	Description and notes
UP00107A	1700001P03Rik, Homeobox protein NK-2 homolog D, Homeobox protein Nkx-2.4, Homeobox NKX2.4, locus 4 (Drosophila), NK2 transcription factor related, Nkx2-4, Nkx2d, tinman	Mus musculus	NK2 transcription factor related, locus 4 (Drosophila)
UP00249A	Cardiac-specific homeobox, Csx, Homeobox protein CSX, Homeobox protein NK-2 homolog Homeobox protein Nkx-2.5, locus 5 (Drosophila), NK2 transcription factor related, Nkx2-5, Nkx2.5, Nkx2e, tinman	Mus musculus	NK2 transcription factor related, locus 5 (Drosophila)
UP00604B	Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, protein CSX, Homeobox protein NK-2 homolog E, homeobox protein Nkx-2.5, NKX2-5_K183E, NKX2.5, NKX2E, NKX4-1	Homo sapiens	homeobox protein Nkx-2.5: This gene encodes a homeobox-containing transcription factor. transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
UP00604C	Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, protein CSX, Homeobox protein NK-2 homolog E, homeobox protein Nkx-2.5, NKX2-5_R161P, NKX2.5, NKX2E, NKX4-1	Homo sapiens	homeobox protein Nkx-2.5: This gene encodes a homeobox-containing transcription factor. transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
UP00604D	Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, protein CSX, Homeobox protein NK-2 homolog E, homeobox protein Nkx-2.5, NKX2-5_R190C, NKX2.5, NKX2E, NKX4-1	Homo sapiens	homeobox protein Nkx-2.5: This gene encodes a homeobox-containing transcription factor. transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
UP00604A	Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, protein CSX, Homeobox protein NK-2 homolog E, homeobox protein Nkx-2.5, NKX2-5_REF, NKX2.5, NKX2E, NKX4-1	Homo sapiens	homeobox protein Nkx-2.5: This gene encodes a homeobox-containing transcription factor. transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
UP00604E	Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, protein CSX, Homeobox protein NK-2 homolog E, homeobox protein Nkx-2.5, NKX2-5_T178M, NKX2.5, NKX2E, NKX4-1	Homo sapiens	homeobox protein Nkx-2.5: This gene encodes a homeobox-containing transcription factor. transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
UP00147A	AV044928, Homeobox protein NK-2 homolog F, Homeobox protein Nkx-2.6, locus (Drosophila), NK2 transcription factor related, Nkx2-6, Nkx2.6, Nkx2f, tinman, Tix	Mus musculus	NK2 transcription factor related, locus 6 (Drosophila)
UP00605B	Homeobox protein NK-2 homolog H, homeobox protein Nkx-2.8, NKX2-8_A94T, Nkx2-9, NKX2G, NKX2H	Homo sapiens	homeobox protein Nkx-2.8
UP00605A	Homeobox protein NK-2 homolog H, homeobox protein Nkx-2.8, NKX2-8_REF, Nkx2-9, NKX2G, NKX2H	Homo sapiens	homeobox protein Nkx-2.8
UP00119A	Homeobox protein NK-2 homolog H, Homeobox protein Nkx-2.8, Homeobox protein locus 9 (Drosophila), NK2 transcription factor related, Nkx2-8, Nkx2-9, Nkx2.9, Nkx2h, tinman	Mus musculus	NK2 transcription factor related, locus 9 (Drosophila)
UP00017A UP00389A	bagpipe, Bax, Homeobox protein Nkx-3.1, locus 1 (Drosophila), NK-3 transcription Nkx3-1, NKX3.1, Nkx3a	Mus musculus	NK-3 transcription factor, locus 1 (Drosophila): Mus musculus homeobox-containing protein mRNA
UP00200A	Homeobox protein Nkx-6.1, locus 1 (Drosophila), NK6 transcription factor related, Nkx6.1, Nkx6a	Mus musculus	NK6 transcription factor related, locus 1 (Drosophila)
UP00238A	9130417I07Rik, locus 3 (Drosophila), NK6 transcription factor related, Nkx6-3, Nkx6.3	Mus musculus	NK6 transcription factor related, locus 3 (Drosophila)
UP00480A	hN1, Neurogenic locus notch homolog protein 1, notch 1, NOTCH1, Translocation-associated notch protein TAN-1	Homo sapiens	notch 1: Functions as a receptor for membrane-bound ligands Jagged1, and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot
UP00481A	AGS2, HJCYS, hN2, notch 2, NOTCH2	Homo sapiens	notch 2: Functions as a receptor for membrane-bound ligands Jagged1, and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot
UP00482A	CADASIL, CASIL, IMF2, notch 3, NOTCH3	Homo sapiens	notch 3: Functions as a receptor for membrane-bound ligands Jagged1, and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot
UP00483A	FLJ16302, INT3, MGC74442, notch 4, NOTCH4	Homo sapiens	notch 4: Functions as a receptor for membrane-bound ligands Jagged1, and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot
UP00606B	BAR, bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, HRR1, MGC163445, NR1H4_C144R, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RIP14, RXR-interacting protein 14	Homo sapiens	bile acid receptor: This gene encodes a ligand-activated transcription factor, shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bi
UP00606A	BAR, bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, HRR1, MGC163445, NR1H4_REF, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RIP14, RXR-interacting protein 14	Homo sapiens	bile acid receptor: This gene encodes a ligand-activated transcription factor, shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bi
UP00607B	ESCS, MGC49976, NR2E3_G56R, Nuclear receptor subfamily 2 group E member photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37	Homo sapiens	photoreceptor-specific nuclear receptor: This protein is part of a large of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects i
UP00607C	ESCS, MGC49976, NR2E3_R76Q, Nuclear receptor subfamily 2 group E member photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37	Homo sapiens	photoreceptor-specific nuclear receptor: This protein is part of a large of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects i
UP00607D	ESCS, MGC49976, NR2E3_R76W, Nuclear receptor subfamily 2 group E member photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37	Homo sapiens	photoreceptor-specific nuclear receptor: This protein is part of a large of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects i
UP00607E	ESCS, MGC49976, NR2E3_R77Q, Nuclear receptor subfamily 2 group E member photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37	Homo sapiens	photoreceptor-specific nuclear receptor: This protein is part of a large of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects i
UP00607A	ESCS, MGC49976, NR2E3_REF, Nuclear receptor subfamily 2 group E member photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37	Homo sapiens	photoreceptor-specific nuclear receptor: This protein is part of a large of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects i
UP00009A	2700033K02Rik, 9430015G03Rik, Apolipoprotein AI regulatory protein 1, Aporp1, Arp-1, Arp1, transcription factor 2, COUP-TF II, COUP-TF2, COUP-TFII, COUPTFB, group F, member 2, Nr2f2, nuclear receptor subfamily 2, SVP40, Tcfcoup2, Tfcoup2	Mus musculus	nuclear receptor subfamily 2, group F, member 2: Mus musculus receptor subfamily 2, group F, member 2 (Nr2f2), transcript variant 1, mRNA.
UP00270A	"MSS1, Nrg1, Transcriptional regulator NRG1, YD5112.01C, YDR043C, Zinc finger protein	Saccharomyces cerevisiae	Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates repression and negatively regulates a variety of processes including filamentous growth and alkaline p...
UP00462A	Negative Regulator of Glucose-controlled genes, Nrg2	Saccharomyces cerevisiae	Negative Regulator of Glucose-controlled genes : Transcriptional repressor that mediates repression and negatively regulates filamentous growth; has similarity to Nrg1p
UP00575A	ARABIDOPSIS NAC DOMAIN PROTEIN 66, At3g61910, F21F14.80, NAC domain-containing protein NAC SECONDARY WALL THICKENING PROMOTING FACTOR2, NAC transcription factor NST2, NAC066, NST2, Protein NAC SECONDARY WALL THICKENING PROMOTING FACTOR 2	Arabidopsis thaliana	NAC transcription factor NST2: Transcription activator of genes involved in of secondary walls. Together with NST1, required for the secondary cell wall thickening of the anther endocethium, which is necessary for anther dehiscence. May also regulates the secondary cell wall lignification of other tissues such as tracheary elements
UP00402A	C18F3.4, NSY-7, Q4PIU8_CAEEL	Caenorhabditis elegans	NSY-7: Putative uncharacterized protein
UP00576A	NTL6, transcription factor NTL6	Arabidopsis thaliana	transcription factor NTL6: Transcriptional activator activated by proteolytic cleavage through intramembrane proteolysis (RIP) (PubMed:20156199, PubMed:19947982). Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene promoters and enhances plant
UP00577A	ANAC040, Arabidopsis NAC domain containing protein 40, F12K2_12, F12K2.12, NTL8, NTM1-like 8	Arabidopsis thaliana	protein NTM1-like 8: Transcriptional activator activated by proteolytic cleavage through intramembrane proteolysis (RIP), probably via metalloprotease activity. Regulates gibberellic acid-mediated salt-responsive repression of seed germination and flowering via FT, thus delaying seed germination under high salinity conditions.
UP00298A	FUN43, Oaf1, Oleate-activated transcription factor 1, YAF1, YAL051W	Saccharomyces cerevisiae	Oleate-activated transcription factor, acts alone and as a heterodimer with activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
UP00216A	7420700M11Rik, AU015708, AU024152, Obox1, oocyte specific homeobox 1	Mus musculus	oocyte specific homeobox 1
UP00239A	Not Available, Obox2, oocyte specific homeobox 2	Mus musculus	oocyte specific homeobox 2
UP00160A	Not Available, Obox3, oocyte specific homeobox 3	Mus musculus	oocyte specific homeobox 3
UP00208A	Not Available, Obox5, oocyte specific homeobox 5	Mus musculus	oocyte specific homeobox 5
UP00109A	Not Available, Obox6, oocyte specific homeobox 6	Mus musculus	oocyte specific homeobox 6
UP00399A	"POU domain, "POU2F1, class 2, NF-A1, Oct-1, OCT1, Octamer-binding transcription 1, OTF-1", OTF1, transcription factor 1"	Homo sapiens	"POU domain, class 2, transcription factor 1": "POU domain, class transcription factor 1"
UP00178A	Nobox, OG2 homeobox gene, Og2x	Mus musculus	OG2 homeobox gene
UP00027A	odd-skipped related 1 (Drosophila), Odd1, Osr1, Protein odd-skipped-related 1	Mus musculus	odd-skipped related 1 (Drosophila): Mus musculus HCM5520 gene, VIRTUAL TRANSCRIPT, sequence, genomic survey sequence
UP00052A	odd-skipped related 2 (Drosophila), Osr2, Protein odd-skipped-related 2	Mus musculus	odd-skipped related 2 (Drosophila): odd-skipped related 2 (Drosophila) (Osr2), mRNA
UP00237A	Homeobox protein orthopediaÃƒÆ’Ã†â€™Ãƒâ€ Ã¢â‚¬â„¢ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬Ãƒâ€¦Ã‚Â¡, orthopedia homolog (Drosophila), Otp	Mus musculus	orthopedia homolog (Drosophila)
UP00229A	A730044F23Rik, Homeobox protein OTX1, jv, orthodenticle homolog 1 (Drosophila), Otx-1,	Mus musculus	orthodenticle homolog 1 (Drosophila)
UP00267A	Homeobox protein OTX2, orthodenticle homolog 2 (Drosophila), Otx-2, Otx2	Mus musculus	orthodenticle homolog 2 (Drosophila)
UP00608B	bA504H3.3, EUROIMAGE566589, hOvo2, OVOL2_D228E, transcription factor Ovo-like 2, Zinc finger 339, ZNF339	Homo sapiens	transcription factor Ovo-like 2: Zinc-finger transcription repressor factor. Plays a role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.
UP00608A	bA504H3.3, EUROIMAGE566589, hOvo2, OVOL2_REF, transcription factor Ovo-like 2, Zinc finger 339, ZNF339	Homo sapiens	transcription factor Ovo-like 2: Zinc-finger transcription repressor factor. Plays a role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.
UP00609B	CDHS, HuP2, MGC120381, MGC120382, MGC120383, MGC120384, MGC134778, paired box protein PAX3_G48R, WS1, WS3	Homo sapiens	paired box protein Pax-3: This gene is a member of paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent
UP00609C	CDHS, HuP2, MGC120381, MGC120382, MGC120383, MGC120384, MGC134778, paired box protein PAX3_N47H, WS1, WS3	Homo sapiens	paired box protein Pax-3: This gene is a member of paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent
UP00609D	CDHS, HuP2, MGC120381, MGC120382, MGC120383, MGC120384, MGC134778, paired box protein PAX3_N47K, WS1, WS3	Homo sapiens	paired box protein Pax-3: This gene is a member of paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent

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