Transcription Factor
| Accessions: | Otx1_DBD (HumanTF 1.0), UP00229A (UniPROBE 20160601) |
| Names: | Homeobox protein OTX1, Orthodenticle homolog 1, Otx1, OTX1_MOUSE, A730044F23Rik, jv, orthodenticle homolog 1 (Drosophila), Otx-1 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P80205 |
| Description: | orthodenticle homolog 1 (Drosophila) |
| Notes: | Ensembl ID: ENSMUSG00000005917; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 DLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRV 60 61 QVWFKNRRAKCRQQQQSGNGTKTRPVKKKSSPV |
| Interface Residues: | 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 4j19_B, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 5zfz_A, 1fjl_B, 1ig7_A, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 1au7_A, 2hos_A, 4cyc_A, 6m3d_C, 5flv_I, 1b72_A, 3l1p_A, 5zjt_E, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 1k61_B, 8g87_X, 1o4x_A |
| Binding Motifs: | UP00229A_1 dgwrgGGATTAAtwtwy Otx1_DBD_1 kwTAATCCGATTAdc Otx1_DBD_2 wTAATCCk |
| Binding Sites: | AATAATCC ACGGATTA ACTAATCC AGGATTAA AGGATTAG AGGGATTA ATAATCCC ATAATCCG ATTAATCC CCGGATTA CGGATTAA CTAATCCC CTTAATCC GAGGATTA GCTAATCC GGATTAAA GGATTAAC GGATTATA GGGATTAA GGGGATTA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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