Transcription Factor
| Accessions: | UP00399A (UniPROBE 20160601) |
| Names: | "POU domain, "POU2F1, class 2, NF-A1, Oct-1, OCT1, Octamer-binding transcription factor 1, OTF-1", OTF1, transcription factor 1" |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | "POU domain, class 2, transcription factor 1": "POU domain, class 2, transcription factor 1" |
| Length: | 766 |
| Pfam Domains: | 304-377 Pou domain - N-terminal to homeobox domain 403-459 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MADGGAASQDESSAAAAAAADSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGG 60 61 AISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAI 120 121 PQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASA 180 181 ATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQG 240 241 LLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTP 300 301 SLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFK 360 361 NMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKS 420 421 FLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSP 480 481 TSLVATTPSLVTSSAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASS 540 541 AVTSPSLSPSPSASASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAAL 600 601 QGAAQLPANASLAAMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLA 660 661 TIQALASGGSLPITSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAA 720 721 ASAGNSAPVASLHATSTSAESIQNSLFTVASASGAASTTTTASKAQ |
| Interface Residues: | 329, 345, 346, 347, 348, 350, 351, 357, 361, 402, 403, 404, 405, 406, 407, 444, 445, 447, 448, 451, 452, 455, 456, 459 |
| 3D-footprint Homologues: | 7u0g_M, 3d1n_M, 3l1p_A, 1o4x_A, 1e3o_C, 1au7_A, 7xrc_C, 2xsd_C, 8g87_X, 4j19_B, 3a01_E, 3cmy_A, 5jlw_D, 1puf_A, 1fjl_B, 5zfz_A, 4cyc_A, 1ig7_A, 5zjt_E, 2h1k_B, 3lnq_A, 2lkx_A, 6m3d_C, 1zq3_P, 1jgg_B, 6es3_K, 2ld5_A, 1nk2_P, 7q3o_C, 5hod_A, 2hdd_A, 3rkq_B, 2r5y_A, 2hos_A, 1b72_A, 7psx_B, 1le8_A, 4qtr_D, 1k61_B, 4xrs_G, 5flv_I, 1du0_A |
| Binding Motifs: | UP00399A_1 ywwradwTwTGCAwAwtsarwm |
| Binding Sites: | ATGCAAAT ATATTCAT AATATGCA AATATTCA AATTATGC AATTATTC ACTAATTA ATATGCAA ATATGCAT ATGAATAA ATGCATAA ATTAATTA ATTATGCA ATTATTCA ATTTAAAT CTAATTAA GCTAATTA TATGAATA TATGCAAA TATGCATA |
| Publications: | Berger M.F, Philippakis A.A, Qureshi A.M, He F.S, Estep P.W, Bulyk M.L. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nature biotechnology 24:1429-35 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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