Transcription Factor

						

			
Accessions: UP00608A (UniPROBE 20160601)

			
Names: bA504H3.3, EUROIMAGE566589, hOvo2, OVOL2_REF, transcription factor Ovo-like 2, Zinc finger protein 339, ZNF339
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: transcription factor Ovo-like 2: Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.
Length: 148
Pfam Domains:     15-37 C2H2-type zinc finger
    15-35 Zinc finger, C2H2 type
    30-53 Zinc-finger double domain
    44-65 C2H2-type zinc finger
    45-65 Zinc finger, C2H2 type
    57-82 Zinc-finger double domain
    71-94 Zinc finger, C2H2 type
    71-91 Zinc-finger of C2H2 type
    71-94 C2H2-type zinc finger
  110-133 C2H2-type zinc finger
  110-133 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 KIKFTTGTCSDSVVHSCDLCGKGFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKR   60
  61 HVRTHTGIRPYKCNVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGP  120
 121 TQEDLYLHVNSAHPGSSFLKKTSKKLAA
Interface Residues: 25, 26, 27, 28, 29, 31, 32, 34, 35, 38, 53, 54, 55, 56, 57, 59, 60, 61, 72, 81, 82, 83, 84, 85, 86, 87, 88, 89, 92, 102, 105, 119, 120, 121, 122, 123, 124, 126, 127
3D-footprint Homologues: 6jnm_A, 5und_A, 2gli_A, 1g2f_F, 7eyi_G, 8ssu_A, 5v3j_F, 6blw_A, 5kkq_D, 1ubd_C, 4x9j_A, 1mey_C, 5kl3_A, 7ysf_A, 6wmi_A, 5ei9_F, 2kmk_A, 8ssq_A, 7w1m_H, 2lt7_A, 2i13_A, 6e94_A, 6a57_A, 2jpa_A, 3uk3_C, 8cuc_F, 7y3l_A, 7n5w_A, 1tf3_A, 5k5i_A, 1tf6_A, 6ml4_A, 1llm_D, 2wbs_A, 6u9q_A, 5yel_A, 7txc_E, 2drp_D, 1f2i_J, 4m9v_C, 8h9h_G, 7y3m_I, 8gn3_A, 3jso_B, 5yj3_D
Binding Motifs: UP00608A_1 wtawktrrdACCGTTAymygkkk
Binding Sites: AACCGTTA
ACCGTTAA
ACCGTTAT
GACCGTTA
AATAACGG
ACCCGTTA
ACCGTTAC
ACCGTTAG
ATAACGGA
ATAACGGG
CACCGTTA
CATAACGG
CCGTTACC
CCGTTATA
CCGTTATC
GTAACGGA
GTCCGTTA
TAACGGAA
TAACGGGA
TAACGGTA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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