Transcription Factor
| Accessions: | UP00607B (UniPROBE 20160601) |
| Names: | ESCS, MGC49976, NR2E3_G56R, Nuclear receptor subfamily 2 group E member 3, photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | photoreceptor-specific nuclear receptor: This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects i |
| Length: | 109 |
| Pfam Domains: | 18-87 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 PGRWGLGEDPTGVSPSLQCRVCGDSSSRKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAG 60 61 MCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMES |
| Interface Residues: | 27, 28, 30, 31, 37, 38, 40, 41, 44, 45, 70, 92, 94, 96 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B |
| Binding Motifs: | UP00607B_1 rwwagrakGGATCAhryscrgwm |
| Binding Sites: | AGGGATCA AGGGGTCA AGGGTCAA ATGACCCC ATGATCCC GGGGTCAA GGGTCAAA GGGTCAAC AGGATCAA CGGGATCA CGTGACCC CTTGATCC GGGATCAA GGGATCAC GTGACCCA GTGATCCA TAGGATCA TGATCCAA TGATCCCA TGGATCAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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