Transcription Factor
| Accessions: | UP00483A (UniPROBE 20160601) |
| Names: | FLJ16302, INT3, MGC74442, notch 4, NOTCH4 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | notch 4: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot |
| Length: | 431 |
| Pfam Domains: | 112-156 Ankyrin repeat 145-215 Ankyrin repeats (3 copies) 160-190 Ankyrin repeat 160-187 Ankyrin repeat 162-213 Ankyrin repeats (many copies) 179-234 Ankyrin repeats (many copies) 193-224 Ankyrin repeat 224-290 Ankyrin repeats (3 copies) 226-258 Ankyrin repeat 227-268 Ankyrin repeats (many copies) 248-300 Ankyrin repeats (many copies) 260-291 Ankyrin repeat 262-313 Ankyrin repeats (many copies) 272-345 Ankyrin repeats (3 copies) 279-333 Ankyrin repeats (many copies) 294-321 Ankyrin repeat |
| Sequence: (in bold interface residues) | 1 RREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEG 60 61 EEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSA 120 121 VCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLL 180 181 EAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVE 240 241 DLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 300 301 AREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPG 360 361 REAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAY 420 421 SHCRSLSGVGA |
| Interface Residues: | 40, 47, 53, 55, 63, 74, 379 |
| 3D-footprint Homologues: | 5n8r_B, 6cnb_R, 8a0x_D |
| Binding Motifs: | UP00483A_1 tykrmwhcvTGGGAAccmswadg |
| Binding Sites: | AGTTCCCA ATGGGAAC ATTCCCAC CATGGGAA CCGTGGGA CCTGGGAA CGTGGGAA CGTGGGAG CGTTCCCA CTGGGAAC CTTCCCAC GCTCCCAC GGTGGGAA GGTTCCCA GTGGGAAA GTGGGAAC GTTTCCCA TATGGGAA TGGGAACA TGTGGGAA |
| Publications: | Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One : (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.