Transcription Factor
| Accessions: | UP00483A (UniPROBE 20160601) |
| Names: | FLJ16302, INT3, MGC74442, notch 4, NOTCH4 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | notch 4: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot |
| Length: | 431 |
| Pfam Domains: | 112-156 Ankyrin repeat 145-215 Ankyrin repeats (3 copies) 160-190 Ankyrin repeat 160-187 Ankyrin repeat 162-213 Ankyrin repeats (many copies) 179-234 Ankyrin repeats (many copies) 193-224 Ankyrin repeat 224-290 Ankyrin repeats (3 copies) 226-258 Ankyrin repeat 227-268 Ankyrin repeats (many copies) 248-300 Ankyrin repeats (many copies) 260-291 Ankyrin repeat 262-313 Ankyrin repeats (many copies) 272-345 Ankyrin repeats (3 copies) 279-333 Ankyrin repeats (many copies) 294-321 Ankyrin repeat |
| Sequence: (in bold interface residues) | 1 RREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEG 60 61 EEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSA 120 121 VCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLL 180 181 EAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVE 240 241 DLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 300 301 AREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPG 360 361 REAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAY 420 421 SHCRSLSGVGA |
| Interface Residues: | 236, 237, 259, 270, 379 |
| 3D-footprint Homologues: | 8ipp_B, 8a0x_D |
| Binding Motifs: | UP00483A_1 tykrmwhcvTGGGAAccmswadg |
| Binding Sites: | AGTTCCCA ATGGGAAC ATTCCCAC CATGGGAA CCGTGGGA CCTGGGAA CGTGGGAA CGTGGGAG CGTTCCCA CTGGGAAC CTTCCCAC GCTCCCAC GGTGGGAA GGTTCCCA GTGGGAAA GTGGGAAC GTTTCCCA TATGGGAA TGGGAACA TGTGGGAA |
| Publications: | Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One : (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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