Transcription Factor
| Accessions: | UP00480A (UniPROBE 20160601) |
| Names: | hN1, Neurogenic locus notch homolog protein 1, notch 1, NOTCH1, TAN1, Translocation-associated notch protein TAN-1 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | notch 1: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot |
| Length: | 367 |
| Pfam Domains: | 113-198 Ankyrin repeats (3 copies) 120-165 Ankyrin repeat 154-225 Ankyrin repeats (3 copies) 159-205 Ankyrin repeats (many copies) 168-195 Ankyrin repeat 168-199 Ankyrin repeat 170-211 Ankyrin repeats (many copies) 187-242 Ankyrin repeats (many copies) 198-265 Ankyrin repeats (3 copies) 201-231 Ankyrin repeat 230-298 Ankyrin repeats (3 copies) 234-266 Ankyrin repeat 235-283 Ankyrin repeats (many copies) 258-308 Ankyrin repeats (many copies) 268-299 Ankyrin repeat 270-321 Ankyrin repeats (many copies) 280-356 Ankyrin repeats (3 copies) 302-326 Ankyrin repeat 302-331 Ankyrin repeat |
| Sequence: (in bold interface residues) | 1 RRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLET 60 61 KKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPD 120 121 GFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSR 180 181 SDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLI 240 241 LAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNR 300 301 EETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVR 360 361 SPQLHGA |
| Interface Residues: | 61, 64, 65, 80, 229, 230, 231 |
| 3D-footprint Homologues: | 6xh7_H, 6ldi_G, 5b2o_A |
| Binding Motifs: | UP00480A_1 tkwksmsCGTGGGAAccastsb UP00480A_2 ytaawamaAsgArm UP00480A_3 wakwstkarTGGGAAmtwwbmkd UP00480A_4 wtmccrTGGGAAcwwk UP00480A_5 ksmscgTGGGAayswst UP00480A_6 yckwwhscrTGGGAAmywkwkrg UP00480A_7 yykrcaycgTGGGAACcvcdwtg |
| Binding Sites: | AAGTACTT AGGGGGGA ATTAATTC ATTTTTTA CGGAAGAA CGTGTGAA GCGTGGGA TTATAAAA AAAAAGGG AAGTAAAA AAGTGAAT AATGGGAA ACAGATAA ACTGGGAA AGAAAGGG AGTGAGAA AGTGGGAA AGTGGGAT AGTTCCCA ATGGGAAA ATGGGAAC ATTCCCAC ATTTCCCA CATGGGAA CCCCCTCC CCGAGTGA CCGTGGGA CCTGGGAA CGATATCG CGTGAGAA CGTGGGAA CGTGGGAG CGTTCCCA CTGGGAAA CTGGGAAC CTTCCCAC CTTTCCCA CTTTCTCA CTTTTCCC GAGAAACA GATTCCCA GCTCCCAC GGTGGGAA GGTTCCCA GTGAGAAC GTGGGAAA GTGGGAAC GTTTCCCA TATGGGAA TATTGAAA TCCCACGA TGGGAAAA TGGGAACA TGTGGGAA |
| Publications: | Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One : (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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