Transcription Factor
| Accessions: | UP00482A (UniPROBE 20160601) |
| Names: | CADASIL, CASIL, IMF2, notch 3, NOTCH3 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | notch 3: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot |
| Length: | 372 |
| Pfam Domains: | 121-169 Ankyrin repeat 152-233 Ankyrin repeats (3 copies) 167-209 Ankyrin repeats (many copies) 172-202 Ankyrin repeat 172-200 Ankyrin repeat 174-215 Ankyrin repeats (many copies) 191-246 Ankyrin repeats (many copies) 205-235 Ankyrin repeat 222-302 Ankyrin repeats (3 copies) 238-269 Ankyrin repeat 240-292 Ankyrin repeats (many copies) 243-333 Ankyrin repeats (3 copies) 262-312 Ankyrin repeats (many copies) 272-302 Ankyrin repeat 274-325 Ankyrin repeats (many copies) 276-357 Ankyrin repeats (3 copies) 306-330 Ankyrin repeat 306-335 Ankyrin repeat |
| Sequence: | KREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECP EAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGP DGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAA RYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGS TALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDM QDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQP SGPRSPPGPHGL |
| Binding Motifs: | UP00482A_1 yyckwwhsCgTGGGAAmywytkd |
| Binding Sites: | CGTGTGAA AGTTCCCA ATGGGAAA ATGGGAAC ATTCCCAC CATGGGAA CCGTGGGA CCTGGGAA CGTGGGAA CTGGGAAA CTGGGAAC CTTTCCCA GATTCCCA GGTGGGAA GGTTCCCA GTGGGAAA GTGGGAAC GTTTCCCA TGGGAAAA TGTGGGAA |
| Publications: | Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One : (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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