Transcription Factor

						

			
Accessions: UP00607A (UniPROBE 20160601)

			
Names: ESCS, MGC49976, NR2E3_REF, Nuclear receptor subfamily 2 group E member 3, photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: photoreceptor-specific nuclear receptor: This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects i
Length: 109
Pfam Domains:     18-87 Zinc finger, C4 type (two domains)
Sequence: 
(in bold interface residues)		   1 PGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAG   60
  61 MCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMES
Interface Residues: 27, 28, 30, 31, 37, 38, 40, 41, 44, 45, 70, 92, 94, 96
3D-footprint Homologues: 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B
Binding Motifs: UP00607A_1 kmwdwycAAAGATCAagmktad
Binding Sites: AAAGGTCA
AAGATCAA
AAGGTCAA
AAGGTCAC
AGATCAAT
AGGTCACG
GAGATCAA
TAAGATCA
AAAGATCA
AAGATCAC
AAGATCAG
AAGATCAT
AGAGATCA
AGATCAAC
AGATCAAG
AGATCACG
CAAGATCA
GAAGATCA
GAGATCAC
TGAGATCA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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