Transcription Factor
| Accessions: | UP00605A (UniPROBE 20160601) |
| Names: | Homeobox protein NK-2 homolog H, homeobox protein Nkx-2.8, NKX2-8_REF, Nkx2-9, NKX2.8, NKX2G, NKX2H |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein Nkx-2.8 |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVKI 60 61 WFQNHRYKLKRARAPGAAESPDLAAS |
| Interface Residues: | 14, 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 71, 72, 73 |
| 3D-footprint Homologues: | 4j19_B, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 2lkx_A, 1nk2_P, 1zq3_P, 7q3o_C, 1puf_B, 6es3_K, 2ld5_A, 1jgg_B, 7psx_B, 3rkq_B, 2hdd_A, 1au7_A, 2r5y_A, 4xrs_G, 2hos_A, 1b72_A, 6m3d_C, 5flv_I, 3lnq_A, 5zjt_E, 3a01_E, 5jlw_D, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 5hod_A, 4xrm_B, 4cyc_A, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00605A_1 twwrrrdCCACTyGAvwtysks |
| Binding Sites: | AAGTACTT ATAAGTGC CACTTATC CACTTGAA CACTTGAG CCACTCAA CCACTCGA CCACTTAA CCACTTCA CCACTTGA GAGTACTC GCACTTCA GCACTTGA GGCACTTA CACTCAAG CACTCGAA CACTCGAG CACTTATG GCACTCAA GCACTCGA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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