Transcription Factor
| Accessions: | UP00147A (UniPROBE 20160601) |
| Names: | AV044928, Homeobox protein NK-2 homolog F, Homeobox protein Nkx-2.6, locus 6 (Drosophila), NK2 transcription factor related, Nkx2-6, Nkx2.6, Nkx2f, tinman, Tix |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P43688 |
| Description: | NK2 transcription factor related, locus 6 (Drosophila) |
| Length: | 93 |
| Pfam Domains: | 17-72 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GDMRRGGPVSTRTRPQRKSRVLFSQAQVLALERRFKQQRYLTAPEREHLASALQLTSTQV 60 61 KIWFQNRRYKSKSQRQDQTLELAGHPLAPRRVA |
| Interface Residues: | 12, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 3a01_E, 3d1n_M, 5zfz_A, 1fjl_B, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 1mnm_C, 1nk2_P, 1zq3_P, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 1au7_A, 5flv_I, 5zjt_E, 4j19_B, 7psx_B, 1b72_A, 3lnq_A, 2hdd_A, 3rkq_B, 2r5y_A, 1jgg_B, 5jlw_D, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1k61_B, 3l1p_A, 1o4x_A, 8g87_X, 5hod_A, 4qtr_D, 1du0_A, 1puf_B |
| Binding Motifs: | UP00147A_1 trAkCCACTTrAvwtt |
| Binding Sites: | AACCACTT AAGTACTT ACCACTTA ACTTAAGT ATAAGTGG CACTTAAA CACTTAAC CACTTAAG CACTTGAA CACTTGAC CACTTGAG CCACTTAG CCACTTGA CCCACTTA GCACTTAA GCACTTGA GCCACTTA GTACTTAA GTACTTGA TAAGTGGA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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