Transcription Factor
| Accessions: | UP00249A (UniPROBE 20160601) |
| Names: | Cardiac-specific homeobox, Csx, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, locus 5 (Drosophila), NK2 transcription factor related, Nkx2-5, Nkx2.5, Nkx2e, tinman |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P42582 |
| Description: | NK2 transcription factor related, locus 5 (Drosophila) |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 DKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQV 60 61 KIWFQNRRYKCKRQRQDQTLELLGPPPPPARRI |
| Interface Residues: | 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 4j19_B, 6a8r_A, 3d1n_M, 1fjl_B, 5zfz_A, 2h1k_B, 1puf_A, 1ig7_A, 5zjt_E, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 1jgg_B, 2hos_A, 1au7_A, 4xrs_G, 3a01_E, 1b72_A, 5flv_I, 3lnq_A, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 5jlw_D, 1e3o_C, 2xsd_C, 7xrc_C, 1le8_A, 1puf_B, 4xrm_B, 4cyc_A, 1k61_B, 3l1p_A, 1o4x_A, 8g87_X, 4qtr_D, 1mnm_C, 1du0_A |
| Binding Motifs: | UP00249A_1 hrakCCACTTrAawty |
| Binding Sites: | AAGTACTT AAGTGGCT ACCACTTA ACTTAAGT ATAAGTGG CAAGTGGC CACTTAAG CACTTATA CACTTGAA CACTTGAG CCACTTAA CCACTTAG CCACTTCA CCACTTGA CCCACTTA GCACTTAA GCACTTGA GCCACTTA GTACTTGA TAAGTGGA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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