Transcription Factor

						

			
Accessions: UP00607D (UniPROBE 20160601)

			
Names: ESCS, MGC49976, NR2E3_R76W, Nuclear receptor subfamily 2 group E member 3, photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: photoreceptor-specific nuclear receptor: This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects i
Length: 109
Pfam Domains:     18-87 Zinc finger, C4 type (two domains)
Sequence: 
(in bold interface residues)		   1 PGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVWRRLIYRCQVGAG   60
  61 MCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMES
Interface Residues: 27, 28, 30, 31, 37, 38, 40, 41, 44, 45, 70, 92, 94, 96
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A
Binding Motifs: UP00607D_1 twsywmyaTATwTAsTgstwwma
Binding Sites: ACGTAATA
AGATAAGA
ATAATTAT
ATATTATG
TATTTAAA
ACATACAT
ACTCAATA
AGTATATA
ATAACTAT
ATAATACA
ATAGAAAT
ATATGCAC
ATATGTAC
ATGTAATA
ATGTATTA
CATAACTA
GATAGTTA
GTAATCAA
TAGATATA
TCTACAAA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.