DNA Binding Motif

						

			
Accessions: UP00607D_1 (UniPROBE 20160601)

			
Names: ESCS, MGC49976, NR2E3_R76W_R1, Nuclear receptor subfamily 2 group E member 3, photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 23
Consensus: twsywmyaTATwTAsTgstwwma
Weblogo: 
PSSM: P0      A      C      G      T
01   0.10   0.21   0.11   0.58      t
02   0.32   0.24   0.11   0.33      w
03   0.20   0.29   0.40   0.12      s
04   0.18   0.26   0.12   0.44      y
05   0.26   0.19   0.20   0.34      w
06   0.38   0.33   0.11   0.18      m
07   0.23   0.33   0.08   0.36      y
08   0.64   0.14   0.05   0.17      a
09   0.08   0.08   0.06   0.77      T
10   0.86   0.05   0.05   0.03      A
11   0.09   0.08   0.09   0.74      T
12   0.33   0.24   0.17   0.25      w
13   0.19   0.03   0.10   0.68      T
14   0.68   0.06   0.17   0.09      A
15   0.15   0.29   0.41   0.15      s
16   0.15   0.04   0.11   0.70      T
17   0.22   0.14   0.57   0.07      g
18   0.22   0.28   0.41   0.09      s
19   0.18   0.21   0.11   0.50      t
20   0.48   0.05   0.10   0.36      w
21   0.39   0.17   0.11   0.33      w
22   0.35   0.38   0.12   0.15      m
23   0.61   0.10   0.20   0.08      a
Binding TFs: UP00607D (Zinc finger, C4 type (two domains))
Binding Sites: ACGTAATA
AGATAAGA
ATAATTAT
ATATTATG
TATTTAAA
ACATACAT
ACTCAATA
AGTATATA
ATAACTAT
ATAATACA
ATAGAAAT
ATATGCAC
ATATGTAC
ATGTAATA
ATGTATTA
CATAACTA
GATAGTTA
GTAATCAA
TAGATATA
TCTACAAA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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