Transcription Factor
| Accessions: | UP00481A (UniPROBE 20160601) |
| Names: | AGS2, HJCYS, hN2, notch 2, NOTCH2 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | notch 2: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot |
| Length: | 377 |
| Pfam Domains: | 125-172 Ankyrin repeat 153-230 Ankyrin repeats (3 copies) 169-208 Ankyrin repeats (many copies) 175-203 Ankyrin repeat 175-206 Ankyrin repeat 178-218 Ankyrin repeats (many copies) 194-249 Ankyrin repeats (many copies) 237-304 Ankyrin repeats (3 copies) 241-273 Ankyrin repeat 262-315 Ankyrin repeats (many copies) 274-306 Ankyrin repeat 277-328 Ankyrin repeats (many copies) 286-363 Ankyrin repeats (3 copies) 309-333 Ankyrin repeat 309-338 Ankyrin repeat |
| Sequence: | KRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDE GPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVN VRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALH LAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMN DGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGAN RDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLL DEYNVTPSPPGTVLTSA |
| Binding Motifs: | UP00481A_1 tmkrmaycvTGGGAAccmbdwkg UP00481A_2 cwckwwwsCrTGGGAAmhwktkd |
| Binding Sites: | GCGTGGGA AGTTCCCA ATGGGAAA ATGGGAAC ATTCCCAC CATGGGAA CCGTGGGA CCTGGGAA CGTGAGAA CGTGGGAA CGTGGGAG CTGGGAAC CTTTCCCA GCTCCCAC GGTGGGAA GGTTCCCA GTGGGAAA GTGGGAAC GTTTCCCA TATGGGAA TGGGAAAA TGTGGGAA |
| Publications: | Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One : (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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