Transcription Factor
| Accessions: | UP00107A (UniPROBE 20160601) |
| Names: | 1700001P03Rik, Homeobox protein NK-2 homolog D, Homeobox protein Nkx-2.4, Homeobox protein NKX2.4, locus 4 (Drosophila), NK2 transcription factor related, Nkx2-4, Nkx2d, tinman |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q9EQM3 |
| Description: | NK2 transcription factor related, locus 4 (Drosophila) |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 ADAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQV 60 61 KIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPP |
| Interface Residues: | 16, 17, 18, 19, 20, 21, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 4j19_B, 1puf_A, 1zq3_P, 6a8r_A, 1fjl_B, 3cmy_A, 1ig7_A, 3d1n_M, 5zfz_A, 1nk2_P, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 1jgg_B, 5flv_I, 5zjt_E, 3a01_E, 2h1k_B, 5hod_A, 1au7_A, 3lnq_A, 2hdd_A, 6m3d_C, 5jlw_D, 1b72_A, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 7psx_B, 3l1p_A, 1e3o_C, 7xrc_C, 1le8_A, 2xsd_C, 6fqp_B, 6fqq_E, 1k61_B, 1o4x_A, 4qtr_D, 8g87_X, 1mnm_C, 1du0_A, 4cyc_A |
| Binding Motifs: | UP00107A_1 waarCCACTTrAmwty |
| Binding Sites: | AAGTACTC AAGTACTT ACCACTTA ACTTGAGA ATAAGTGG CACTTAAG CACTTATC CACTTCAA CACTTGAA CACTTGAC CACTTGAG CCACTCAA CCACTTAA CCACTTCA CCCACTTA CTCAAGTA GCACTTCA GCACTTGA GTACTTCA GTACTTGA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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