Transcription Factor
| Accessions: | Nkx3-1_DBD (HumanTF 1.0), UP00017A (UniPROBE 20160601), UP00389A (UniPROBE 20160601) |
| Names: | Homeobox protein NK-3 homolog A, Homeobox protein Nkx-3.1, Nkx3-1, NKX31_MOUSE, bagpipe, Bax, locus 1 (Drosophila), NK-3 transcription factor, NKX3.1, Nkx3a |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P97436 |
| Description: | NK-3 transcription factor, locus 1 (Drosophila): Mus musculus homeobox-containing protein Nkx-3.1 mRNA |
| Notes: | Ensembl ID: ENSMUSG00000022061; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 NPGDLASAPQVTKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQV 60 61 KIWFQNRRYKTKRKQLSEDLGVLEKNSPLSLPA |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 3d1n_M, 2h1k_B, 1puf_A, 6a8r_A, 1fjl_B, 3cmy_A, 5zfz_A, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 2r5y_A, 5flv_I, 2hos_A, 1ig7_A, 5zjt_E, 4cyc_A, 7psx_B, 5hod_A, 3l1p_A, 3a01_E, 7q3o_C, 5jlw_D, 6es3_K, 1b72_A, 4xrs_G, 2hdd_A, 3rkq_B, 1le8_A, 2xsd_C, 1e3o_C, 1au7_A, 2h8r_B, 7xrc_C, 1ic8_B, 1du0_A, 1o4x_A, 8g87_X, 1le8_B, 4qtr_D, 1mnm_C, 1puf_B, 1k61_B |
| Binding Motifs: | UP00017A_1 mwwarCCACTTAAsgab UP00389A_1 twywAAGTACTTAaaws Nkx3-1_DBD rcCACTTAa UP00017A_2 vmdsvrrGTACyykgma |
| Binding Sites: | ACACTTAA ACCACTTA ACTTAAGT AGCACTTA AGTACTTA ATAAGTGG CACTTAAA CACTTAAC CACTTAAG CCACTTAA CCACTTAC CCACTTAG CCACTTTA CCCACTTA GCACTTAA GCCACTTA GGCACTTA GGTACTTA GTACTTAA TAAGTGGA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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