Transcription Factor
| Accessions: | UP00606B (UniPROBE 20160601) |
| Names: | BAR, bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, FXR, HRR1, MGC163445, NR1H4_C144R, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RIP14, RXR-interacting protein 14 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | bile acid receptor: This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bi |
| Length: | 120 |
| Pfam Domains: | 15-81 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 PRMGASAGRIKGDELCVVCGDRASGYHYNALTREGCKGFFRRSITKNAVYKCKNGGNCVM 60 61 DMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGR 120 |
| Interface Residues: | 24, 25, 27, 28, 34, 35, 37, 38, 41, 42, 66, 90 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B |
| Binding Motifs: | UP00606B_1 wwmrrawtrAttwAtArtwmAAt |
| Binding Sites: | TAATAAAA AAAAAATA AACAAAAA AATTAATA ATAATATA ATATAATA ATATTATG GATTAAAA AAATGAAA AATAGATA ACACATAA ACATATAA ATAAGAAA ATAAGAAC ATACAAAA ATATAAGA CCTTATTA GATTAATA GTATGATA GTATTAGA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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