Transcription Factor
| Accessions: | T061529_1.02 (CISBP 1.02), UP00462A (UniPROBE 20160601) |
| Names: | NRG2, T061529_1.02;, Negative Regulator of Glucose-controlled genes |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Negative Regulator of Glucose-controlled genes : Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p |
| Notes: | family:C2H2 ZF |
| Length: | 220 |
| Pfam Domains: | 167-194 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MSIGYKDNLMSTILAKDRKCEFPINFECSPSQITLMPEMFSFNNERKYQTLIPLMKTSHL 60 61 IDDDLKDKLNKCAFDFFSGKQANRTSDGTISRLTASGKTSPILPLQNINIVKAENTGNGK 120 121 SDPYSSIKISKPTKTVIKLKSTKTNTAGQRTRHFCKICSTGFTTSGHLSRHNRIHTGEKN 180 181 HICPHEGCGQRFSRHDNCNQHYRTHANKKKRNWKRREASS |
| Interface Residues: | 109, 112, 116, 128, 130, 131, 134, 135, 136, 137, 138, 141, 163, 164, 165, 166, 167, 169, 170, 171, 174, 193, 194, 195, 196, 197, 198, 200, 201, 204, 216 |
| 3D-footprint Homologues: | 2i13_A, 8ssq_A, 8ssu_A, 5kkq_D, 5und_A, 7w1m_H, 6e94_A, 6jnm_A, 8cuc_F, 7y3l_A, 6ml4_A, 3uk3_C, 7n5w_A, 2kmk_A, 1g2f_F, 2lt7_A, 7ysf_A, 6wmi_A, 4x9j_A, 1llm_D, 5kl3_A, 1ubd_C, 5ei9_F, 2jpa_A, 1mey_C, 2drp_D, 1f2i_J, 6blw_A, 5k5i_A, 6u9q_A, 5v3j_F, 2gli_A, 7txc_E, 7eyi_G, 4m9v_C, 8h9h_G, 1tf6_A, 1tf3_A, 7y3m_I, 8gn3_A, 5yj3_D, 2wbs_A, 6a57_A |
| Binding Motifs: | M4204_1.02 mAGGGtcb UP00462A_1 hsrycymAGGGTCCamGkcvwky |
| Binding Sites: | AAGGGTCC ACAGGGTC AGACCCTG AGGGTCCA AGGGTCCC AGGGTCCG CAAGGGTC CAGGGACC CAGGGTCC CAGGGTTC CCAGGGTC GACCCTGA GCGCGCGC AACCCTGA AAGGGACC ACCCTGCA AGGGACCT AGGGCCCT CAGGGACA CAGGGCCC |
| Publications: | Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed] |
| Related annotations: | PaperBLAST |
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