Transcription Factor
| Accessions: | UP00119A (UniPROBE 20160601) |
| Names: | Homeobox protein NK-2 homolog H, Homeobox protein Nkx-2.8, Homeobox protein Nkx-2.9, locus 9 (Drosophila), NK2 transcription factor related, Nkx2-8, Nkx2-9, Nkx2.9, Nkx2h, tinman |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | O70584 |
| Description: | NK2 transcription factor related, locus 9 (Drosophila) |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 LASLRRASPGSDPEKRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRLTPTQV 60 61 KIWFQNHRYKLKRGRAPGITEPSDMAASSDLHA |
| Interface Residues: | 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73, 74, 75 |
| 3D-footprint Homologues: | 5zfz_A, 4j19_B, 1ig7_A, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 2lkx_A, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 1puf_B, 6es3_K, 6m3d_C, 5flv_I, 3lnq_A, 5zjt_E, 3a01_E, 2h1k_B, 1jgg_B, 7psx_B, 3rkq_B, 2hdd_A, 1au7_A, 5jlw_D, 2r5y_A, 4xrs_G, 2hos_A, 1b72_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D, 5hod_A, 4xrm_B, 4cyc_A |
| Binding Motifs: | UP00119A_1 wttwrAGTACTyrAaty |
| Binding Sites: | AAGTACTC ACCACTTA AGCACTTA ATAAGTGC ATAAGTGG CACTTAAA CACTTAAG CACTTATC CACTTGAA CACTTGAG CCACTCAA CCACTTAA CCACTTCA CCACTTGA GAGTACTC GCACTTAA GCACTTCA GCACTTGA GTACTTCA GTACTTGA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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