Transcription Factor

						

			
Accessions: UP00608B (UniPROBE 20160601)

			
Names: bA504H3.3, EUROIMAGE566589, hOvo2, OVOL2_D228E, transcription factor Ovo-like 2, Zinc finger protein 339, ZNF339
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: transcription factor Ovo-like 2: Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.
Length: 148
Pfam Domains:     15-37 C2H2-type zinc finger
    15-35 Zinc finger, C2H2 type
    30-53 Zinc-finger double domain
    44-65 C2H2-type zinc finger
    45-65 Zinc finger, C2H2 type
    57-82 Zinc-finger double domain
    71-94 Zinc finger, C2H2 type
    71-91 Zinc-finger of C2H2 type
    71-94 C2H2-type zinc finger
  110-133 C2H2-type zinc finger
  110-133 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 KIKFTTGTCSDSVVHSCDLCGKGFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKR   60
  61 HVRTHTGIRPYKCNVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGP  120
 121 TQEELYLHVNSAHPGSSFLKKTSKKLAA
Interface Residues: 25, 26, 27, 28, 29, 31, 32, 34, 35, 38, 53, 54, 55, 56, 57, 59, 60, 61, 72, 81, 82, 83, 84, 85, 86, 87, 88, 89, 92, 102, 105, 119, 120, 121, 122, 123, 124, 126, 127
3D-footprint Homologues: 6jnm_A, 5und_A, 2gli_A, 1g2f_F, 7eyi_G, 8ssu_A, 5v3j_F, 6blw_A, 5kkq_D, 1ubd_C, 4x9j_A, 1mey_C, 5kl3_A, 7ysf_A, 6wmi_A, 5ei9_F, 2kmk_A, 8ssq_A, 7w1m_H, 2lt7_A, 2i13_A, 6e94_A, 6a57_A, 2jpa_A, 3uk3_C, 8cuc_F, 7y3l_A, 7n5w_A, 1tf3_A, 5k5i_A, 1tf6_A, 6ml4_A, 1llm_D, 2wbs_A, 6u9q_A, 5yel_A, 7txc_E, 2drp_D, 1f2i_J, 4m9v_C, 8h9h_G, 7y3m_I, 8gn3_A, 3jso_B, 5yj3_D
Binding Motifs: UP00608B_1 rwywtvyArmTAACGGwywmayc
Binding Sites: AACCGTTA
ACCGTTAA
ACCGTTAT
ATCCGTTA
GACCGTTA
ACCCGTTA
ACCGTTAC
ACCGTTAG
AGTAACGG
CACCGTTA
CCGTTACA
CCGTTACC
CCGTTAGA
CCGTTATA
CCGTTATC
CTAACGGA
GTAACGGA
GTCCGTTA
TAACGGAA
TAACGGTA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.