Transcription Factor
| Accessions: | ONECUT2_DBD (HumanTF 1.0), ONECUT2_TF2 (HumanTF2 1.0), ONECUT2 (HT-SELEX2 May2017) |
| Names: | Hepatocyte nuclear factor 6-beta, HNF-6-beta, OC-2, One cut domain family member 2, One cut homeobox 2, ONEC2_HUMAN, ONECUT2, Transcription factor ONECUT-2, ENSG00000119547 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O95948 |
| Notes: | Ensembl ID: ENSG00000119547; DNA-binding domain sequence; TF family: homeodomain+cut; Clone source: Gene synthesis, Ensembl ID: ENSG00000119547; Construct type: TF2(3xFLAG); TF family: Homeodomain_Cut; Clone source: Jolma et al. 2013, TF family: CUT_Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: CUT_Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2b0, TF family: CUT_Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: CUT_Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2, TF family: CUT_Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 198 |
| Pfam Domains: | 22-100 CUT domain 121-174 Homeobox domain |
| Sequence: (in bold interface residues) | 1 VLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQG 60 61 TLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQ 120 121 KKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRRSLEKWQ 180 181 DDLSTGGSSSTSSTCTKA |
| Interface Residues: | 51, 52, 53, 56, 57, 58, 59, 60, 61, 63, 64, 67, 71, 81, 84, 97, 124, 165, 166, 169, 170, 173, 174 |
| 3D-footprint Homologues: | 1au7_A, 2d5v_B, 2o4a_A, 6y93_B, 5hod_A, 3l1p_A, 1e3o_C, 6fqp_B, 1puf_B, 4qtr_D, 6fqq_E, 4xrm_B, 1o4x_A, 8g87_X |
| Binding Motifs: | ONECUT2_DBD aaaAAATCrATAww E2F3_ONECUT2_1 wdsGCGCsmwTATyGAyy E2F3_ONECUT2_2 wdsGCGCshwwTATCGAyy ELK1_ONECUT2_1 rCCGGAAscGATCGATam ELK1_ONECUT2_2 rsCGGAAscGATCGATa ERF_ONECUT2 rCCGGAArtgcsgATCGATy ETV2_ONECUT2_1 rrTCrATAmCGGAAryr ETV2_ONECUT2_2 rATCrATaacCGGAAryg ETV2_ONECUT2_2_3 rcCGGAArygryATCGATy ETV2_ONECUT2_2_3_4 acCGGAWryrrrkATCGATy ETV2_ONECUT2_2_3_4_5 rcCGGAAryrrgsrATCrATr FLI1_ONECUT2 acCGGAWryrmtgrTCGAT GCM1_ONECUT2_1 rTGcGGGwAATCGATr GCM1_ONECUT2_2 rTGcGGGaAATCGATr GCM2_ONECUT2 ATrcGGGyaawmrATCrATa HOXB13_ONECUT2_1 syhrTwAAwATyGAty HOXB13_ONECUT2_2 CYcrTAAAwaTCGaty MEIS1_ONECUT2 TGACAgawAATCrATr MEIS2_ONECUT2_1 kTGACAGcwAATCrATas MEIS2_ONECUT2_2 wTGACAgawAATCGATAm MYBL1_ONECUT2 yAACGgtTATyGAty TEAD4_ONECUT2 rCATwCCryATYGAyy TFAP2C_ONECUT2_1 rATCGATaytkhsCCksrrGssk TFAP2C_ONECUT2_2 rrTCGATvygbttksCCygrGGskr TFAP2C_ONECUT2_2_3 tATCGAyyggwyrtysCCysrGGsga TFAP2C_ONECUT2_2_3_4 tATyGATygbycbrtysCCysrGGsbv ONECUT2_2 ktATyGATyg ONECUT2_5 ktATYGATydt ONECUT2_6 kTATCGATCsgt ONECUT2_methyl_1 kTATTGATyk ONECUT2_methyl_3 kTATTGATTwt ONECUT2_methyl_4 kTATTGATCsGT |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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