DNA Binding Motif

						

			
Accessions: TFAP2C_ONECUT2_1 (HumanTF2 1.0)

			
Names: TFAP2C_ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 23
Consensus: rATCGATaytkhsCCksrrGssk
Weblogo: 
PSSM: P0      A      C      G      T
01    352     25    272     23      r
02    672     20     57      7      A
03      0      0     35    672      T
04      0    672     27     21      C
05    178      0    672     28      G
06    672     26     44     65      A
07      9     26     18    672      T
08    388     66    113    105      a
09    129    246    126    171      y
10    118    161    159    233      t
11    126     95    179    273      k
12    194    182    128    168      h
13    142    397    672     93      s
14      2    672     10      6      C
15      0    672      0     69      C
16    103    235    345    672      k
17    110    213    273     76      s
18    288    119    229     37      r
19    285     28    672     13      r
20     18      0    672      0      G
21     18    439    233     57      s
22    118    192    213    149      s
23    156     92    222    202      k
Type: Heterodimer
Binding TFs: ONECUT2_TF2 (Homeobox domain, CUT domain)
TFAP2C_TF1 (Transcription factor AP-2)
ONECUT2_Full (Homeobox domain, CUT domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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