DNA Binding Motif

						

			
Accessions: ONECUT2_DBD (HumanTF 1.0), MA0756.1 (JASPAR 2024)

			
Names: ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 2, HT-SELEX
Length: 14
Consensus: aaaAAATCrATAww
Weblogo: 
PSSM: P0      A      C      G      T
01   1028    445    539    366      a
02   1363    192    515    307      a
03   2378    254    375    507      a
04   2378    157     83    595      A
05   2378     12    114     20      A
06   2378      1     18      6      A
07      8      8      9   2378      T
08      6   2378      0      5      C
09    893     16   1485      0      r
10   2378      2      1     22      A
11     20     14      0   2378      T
12   2378     84    105    205      A
13   1547    576    238    832      w
14    651    526    237    964      w
Type: Heterodimer
Binding TFs: ONECUT2_DBD (Homeobox domain, CUT domain)
O95948 (Homeobox domain, CUT domain)
O95948
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Samadani U., Costa R. H. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol. Cell. Biol. 16:6273-6284 (1996). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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