DNA Binding Motif

						

			
Accessions: GCM1_ONECUT2_2 (HumanTF2 1.0), UN0548.1 (JASPAR 2024)

			
Names: GCM1_ONECUT2, GCM1::ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: rTGcGGGaAATCGATr
Weblogo: 
PSSM: P0      A      C      G      T
01   1314    245    766    116      r
02    146    250    192   2080      T
03    541     93   2080     11      G
04    422   2080    601    660      c
05    121     44   2080    100      G
06      4      8   2080     34      G
07     16      0   2080      4      G
08    819    349    407    505      a
09   1660     19    304     96      A
10   1886      1    109     84      A
11     34     43     24   2080      T
12     17   2080     10      7      C
13    610    102   2080     70      G
14   2080      9     52    317      A
15     48     20     14   2080      T
16   1102    452    978    489      r
Type: Heterodimer
Binding TFs: GCM1_TF1 (GCM motif protein)
ONECUT2_TF2 (Homeobox domain, CUT domain)
Q9NP62 (GCM motif protein)
ONECUT2_Full (Homeobox domain, CUT domain)
Q9NP62
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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