DNA Binding Motif

						

			
Accessions: TFAP2C_ONECUT2_2_3_4 (HumanTF2 1.0)

			
Names: TFAP2C_ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 27
Consensus: tATyGATygbycbrtysCCysrGGsbv
Weblogo: 
PSSM: P0      A      C      G      T
01    121    179    163    319      t
02    782     56      0     82      A
03     16     34      0    782      T
04      0    498     18    284      y
05     91      0    782     10      G
06    782     14     13     32      A
07     63    221     10    782      T
08     58    490     35    199      y
09    134    155    334    158      g
10    150    212    197    223      b
11    171    212    120    278      y
12    171    256    184    171      c
13     92    250    206    234      b
14    267    182    237     97      r
15    149    191     96    345      t
16    165    220    110    288      y
17     34    494    782    101      s
18      0    782      8      0      C
19      0    782      0    144      C
20     82    495    396    782      y
21    112    378    240     52      s
22    382    150    198     52      r
23     93     11    782      0      G
24      0      0    782      7      G
25      6    488    294     82      s
26     85    233    251    213      b
27    239    206    205    133      v
Type: Heterodimer
Binding TFs: ONECUT2_TF2 (Homeobox domain, CUT domain)
TFAP2C_TF1 (Transcription factor AP-2)
ONECUT2_Full (Homeobox domain, CUT domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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