Transcription Factor
| Accessions: | ONECUT2_Full (HumanTF2 1.0) |
| Names: | Hepatocyte nuclear factor 6-beta, HNF-6-beta, OC-2, One cut domain family member 2, One cut homeobox 2, ONEC2_HUMAN, ONECUT2, Transcription factor ONECUT-2 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | O95948 |
| Notes: | Ensembl ID: ENSG00000119547; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: Homeodomain_Cut; Clone source: Jolma et al. 2013 |
| Length: | 505 |
| Pfam Domains: | 328-406 CUT domain 427-480 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE 60 61 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYR 120 121 PELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHH 180 181 HHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLH 240 241 NAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGH 300 301 TQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRV 360 361 LCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNK 420 421 DRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRR 480 481 SLEKWQDDLSTGGSSSTSSTCTKA* |
| Interface Residues: | 357, 358, 359, 362, 363, 364, 365, 367, 369, 370, 373, 377, 402, 403, 408, 412, 428, 429, 430, 471, 472, 475, 476, 479, 480, 484 |
| 3D-footprint Homologues: | 1au7_A, 2d5v_B, 2o4a_A, 1e3o_C, 3l1p_A, 2lkx_A, 7q3o_C, 6es3_K, 2hdd_A, 5hod_A, 2hos_A, 3rkq_B, 8g87_X, 4qtr_D, 6fqp_B, 4xrm_B, 6fqq_E, 1o4x_A, 1puf_B |
| Binding Motifs: | E2F3_ONECUT2_1 wdsGCGCsmwTATyGAyy E2F3_ONECUT2_2 wdsGCGCshwwTATCGAyy ELK1_ONECUT2_1 rCCGGAAscGATCGATam ELK1_ONECUT2_2 rsCGGAAscGATCGATa ERF_ONECUT2 rCCGGAArtgcsgATCGATy ETV2_ONECUT2_1 rrTCrATAmCGGAAryr ETV2_ONECUT2_2 rATCrATaacCGGAAryg ETV2_ONECUT2_2_3 rcCGGAArygryATCGATy ETV2_ONECUT2_2_3_4 acCGGAWryrrrkATCGATy ETV2_ONECUT2_2_3_4_5 rcCGGAAryrrgsrATCrATr FLI1_ONECUT2 acCGGAWryrmtgrTCGAT GCM1_ONECUT2_1 rTGcGGGwAATCGATr GCM1_ONECUT2_2 rTGcGGGaAATCGATr GCM2_ONECUT2 ATrcGGGyaawmrATCrATa HOXB13_ONECUT2_1 syhrTwAAwATyGAty HOXB13_ONECUT2_2 CYcrTAAAwaTCGaty MEIS1_ONECUT2 TGACAgawAATCrATr MEIS2_ONECUT2_1 kTGACAGcwAATCrATas MEIS2_ONECUT2_2 wTGACAgawAATCGATAm MYBL1_ONECUT2 yAACGgtTATyGAty TEAD4_ONECUT2 rCATwCCryATYGAyy TFAP2C_ONECUT2_1 rATCGATaytkhsCCksrrGssk TFAP2C_ONECUT2_2 rrTCGATvygbttksCCygrGGskr TFAP2C_ONECUT2_2_3 tATCGAyyggwyrtysCCysrGGsga TFAP2C_ONECUT2_2_3_4 tATyGATygbycbrtysCCysrGGsbv |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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