DNA Binding Motif

						

			
Accessions: MEIS2_ONECUT2_2 (HumanTF2 1.0)

			
Names: MEIS2_ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; PWM is from validation experiment performed with full-length TFs and is not included into the dendrograms
Length: 18
Consensus: wTGACAgawAATCGATAm
Weblogo: 
PSSM: P0      A      C      G      T
01    975    454    766   1024      w
02    266    278    183   2995      T
03      0    147   3199     39      G
04   3083     15    259    162      A
05     50   3166     49     68      C
06   3191     10    156      0      A
07    828    337   2750    492      g
08   1154    654    638    774      a
09   2599      0      0   2402      w
10   3215     12      3     66      A
11   3224      2      3      4      A
12      5      0      6   3221      T
13      0   3218     13      6      C
14    345      0   2877      0      G
15   3215     13      5      8      A
16      0     22      0   3221      T
17   2963     76    149    225      A
18   1315    917    293    694      m
Type: Heterodimer
Binding TFs: MEIS2_TF1 (Homeobox domain, Homeobox KN domain)
ONECUT2_TF2 (Homeobox domain, CUT domain)
MEIS2_Full (Homeobox domain, Homeobox KN domain)
ONECUT2_Full (Homeobox domain, CUT domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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