DNA Binding Motif

						

			
Accessions: ETV2_ONECUT2_1 (HumanTF2 1.0), UN0518.1 (JASPAR 2024)

			
Names: ETV2_ONECUT2, ETV2::ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 17
Consensus: rrTCrATAmCGGAAryr
Weblogo: 
PSSM: P0      A      C      G      T
01    826    210    472    200      r
02   1169     34    539     79      r
03      0     22     12   1708      T
04     38   1708     17     33      C
05    943     53    765     55      r
06   1708     19    104      9      A
07     71     21      9   1708      T
08   1708     34    157     87      A
09    494    847    269     98      m
10    347   1708     59      5      C
11      0      8   1708      3      G
12      0      0   1708     21      G
13   1708     21      0     31      A
14   1708    158     17    592      A
15    639    120   1069      0      r
16     69    574    310   1134      y
17    495    381    560    272      r
Type: Heterodimer
Binding TFs: ONECUT2_TF2 (Homeobox domain, CUT domain)
ETV2_TF1 (Ets-domain)
ONECUT2_Full (Homeobox domain, CUT domain)
Q3KNT2 (Ets-domain)
Q3KNT2
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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