DNA Binding Motif

						

			
Accessions: MEIS2_ONECUT2_1 (HumanTF2 1.0)

			
Names: MEIS2_ONECUT2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 18
Consensus: kTGACAGcwAATCrATas
Weblogo: 
PSSM: P0      A      C      G      T
01    373    479    746   1060      k
02    141    109     68   2582      T
03      8     31   2632     29      G
04   2652      0     40     17      A
05      2   2555     33    231      C
06   2613      0    616      0      A
07    120    726   2505    324      G
08    583   1094    340    642      c
09   1749     89     15   2434      w
10   2636      4    125    307      A
11   2505     58    611     96      A
12     13    111     34   2597      T
13     25   2661     13     39      C
14   1120    147   1387     77      r
15   2516     42     45    619      A
16    276    121      0   2549      T
17   2210    531    729    572      a
18    449    900    722    588      s
Type: Heterodimer
Binding TFs: MEIS2_TF1 (Homeobox domain, Homeobox KN domain)
ONECUT2_TF2 (Homeobox domain, CUT domain)
MEIS2_Full (Homeobox domain, Homeobox KN domain)
ONECUT2_Full (Homeobox domain, CUT domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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